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. 2024 Nov;28(22):e70229.
doi: 10.1111/jcmm.70229.

Peribronchial Inflammatory Cell Assessment in COPD Lung Tissues

Maëva A Devilliers  1 , Lynda Saber Cherif  1 , Laure M G Petit  1 , Nathalie Lalun  1 , Arnaud Bonnomet  1   2 , Anne Durlach  1   3 , Gonzague Delepine  1   4 , Myriam Polette  1   3 , Jeanne-Marie Perotin  1   5 , Gaëtan Deslée  1   5 , Valérian Dormoy  1
Affiliations

Peribronchial Inflammatory Cell Assessment in COPD Lung Tissues

Maëva A Devilliers et al. J Cell Mol Med. 2024 Nov.
No abstract available

Keywords: COPD; MGG; inflammation and airway remodelling; lung histology.

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Conflict of interest statement

Gaëtan Deslée reports lecture honoraria from Chiesi and AstraZeneca; outside the submitted work. Valérian Dormoy reports lecture honoraria from Chiesi and AstraZeneca; outside the submitted work. There are no further conflicting interests to disclose.

Figures

FIGURE 1
FIGURE 1
Quantitative analysis of peribronchial neutrophils, lymphocytes, basophils and eosinophils in COPD lung tissues. (a) Example of a microscopic acquisition showing peribronchial accumulation of neutrophils (orange arrow), lymphocytes (red arrow), basophils (blue arrow) and eosinophils (green arrow) in an MGG‐stained FFPE lung resection from a COPD patient. (b) Violin plots showing eosinophil, basophil, neutrophil and lymphocyte counts in the peribronchial regions of COPD (n = 23) and non‐COPD patients (n = 11). The markers for the median and the box indicating the interquartile range are shown in black. (c) Radar charts displaying the square of the Pearson correlation r for the multivariate epithelial remodelling features in non‐COPD (grey lines, n = 4–8) and COPD patients (red lines, n = 8–13) regarding eosinophil, basophil, neutrophil and lymphocyte counts. *p < 0.05, **p < 0.01 in COPD patients. (d) Dot plots showing linear regressions for COPD patients (n = 8–11) regarding eosinophil and neutrophil counts for the ciliated cell surface and Muc5b.
See this image and copyright information in PMC

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