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Review
. 2025 Mar 1:238:1-8.
doi: 10.1016/j.amjcard.2024.11.021. Epub 2024 Nov 23.

Angiography-Derived Fractional Flow Reserve: Newer Data and Future Directions

Dimitrios Strepkos  1 , Jaskanwal Deep Singh Sara  1 , Pedro E P Carvalho  1 , Michaella Alexandrou  1 , Deniz Mutlu  1 , Ozgur S Ser  1 , Arnold H Seto  2 , William F Fearon  3 , Bavana V Rangan  1 , Olga C Mastrodemos  1 , Sandeep Jalli  1 , Konstantinos Voudris  1 , M Nicholas Burke  1 , Yader Sandoval  1 , Emmanouil S Brilakis  4
Affiliations
Review

Angiography-Derived Fractional Flow Reserve: Newer Data and Future Directions

Dimitrios Strepkos et al. Am J Cardiol. .

Abstract

Several novel software systems have been developed for the reconstruction of the coronary artery tree and the calculation of fractional flow reserve (FFR) from coronary artery angiography images without coronary artery instrumentation: FFRangio, Computational pressure-flow dynamics derived FFR, quantitative flow ratio (QFR), and vessel FFR. In this report, we review the current evidence on each software, their contemporary use, and future directions.

Keywords: angiography; coronary revascularization; fractional flow reserve software.

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Conflict of interest statement

Declaration of competing interest Dr. Brilakis reports consulting/speaker honoraria from Abbott Vascular, American Heart Association (associate editor circulation), Amgen, Asahi Intecc, Biotronik, Boston Scientific, Cardiovascular Innovations Foundation (Board of Directors), ControlRad, CSI, Ebix, Elsevier, GE Healthcare (Little Chalfont, United Kingdom), InfraRedx, Medtronic, Siemens, and Teleflex; research support from Regeneron and Siemens; ownership, Hippocrates LLC; and being a shareholder in MHI Ventures and Cleerly Health. Dr. Sandoval reports consulting/speaker honoraria from Abbott Diagnostics, Roche Diagnostics, Zoll, Philips; being JACC Advances associate editor; and holding patent 20,210,401,347. The remaining authors have no competing interest to declare.

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