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. 2025 Dec;46(8):2489-2496.
doi: 10.1007/s00246-024-03702-7. Epub 2024 Nov 24.

The Role of Nt-Pro-Bnp in Predicting Outcome in Pediatric Hypertrophic Cardiomyopathy

Nicoletta Cantarutti  1 , Rachele Adorisio  2 , Sara Di Marzio  1 , Marianna Cicenia  1 , Irma Battipaglia  1 , Erica Mencarelli  3 , Massimo Stefano Silvetti  1 , Antonio Amodeo  3 , Fabrizio Drago  1
Affiliations

The Role of Nt-Pro-Bnp in Predicting Outcome in Pediatric Hypertrophic Cardiomyopathy

Nicoletta Cantarutti et al. Pediatr Cardiol. 2025 Dec.

Abstract

Hypothesis: The aim of the study was to evaluate the correlation between NTproBNP and left ventricular mass (LVM) in children affected by hypertrophic cardiomyopathy (HCM), both asymptomatic, symptomatic, and with implantable cardioverter-defibrillator (ICD).

Methods: A total of 225 pediatric patients were evaluated and 45 were enrolled in the study because met inclusion criteria (age < 18 years; diagnosis of hypertrophic cardiomyopathy; NTproBNP > 600 pg/ml).

Results: The analysis showed a significant correlation between NTproBNP level and LVM (p = 0.024). ANOVA test showed that high level of NTproBNP and LVM were significantly correlated to ICD implantation (p = 0.001; p = 0.003). Multivariate analysis showed NTproBNP as an independent risk factor for ICD implantation (p = 0.035).

Conclusion: Our study showed that NTproBNP levels directly correlated to LVM and disease progression and it was found to be predictive, together with LVM, of ICD implantation.

Keywords: Hypertrophic cardiomyopathy; NTproBNP; Outcome; Pediatric; Risk stratification.

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Conflict of interest statement

Declarations. Conflict of interests: The authors declare no competing interests.

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