Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Nov 21:15357597241280485.
doi: 10.1177/15357597241280485. Online ahead of print.

Mapping Cognition in Epilepsy: From the Lab to the Clinic

Donald Jay Bearden  1   2 , Alena Stasenko  3 , Freya Prentice  4 , Christopher Benjamin  5 , Marla Hamberger  6 , Lauren Reppert  7 , Jana J Jones  8 , Leigh Sepeta  9
Affiliations
Review

Mapping Cognition in Epilepsy: From the Lab to the Clinic

Donald Jay Bearden et al. Epilepsy Curr. .

Abstract

In this article, we provide an overview of our panel presentation at the American Epilepsy Society meeting in December2023. Our presentation reviewed functional mapping methods for epilepsy surgery including well-established and newer methods, focusing mostly on language and memory. Dr Leigh Sepeta (Chair) and Dr Jana Jones (Chair) organized the presentation, which included 5 presenters. Dr Christopher Benjamin discussed the history and current and future mapping practices using functional magnetic resonance imaging; Ms. Freya Prentice reviewed functional mapping of language and memory in pediatric epilepsy; Dr Marla Hamberger compared pros and cons of functional mapping between subdural electrodes and stereoelectroencephalography (SEEG); Dr Donald J. Bearden presented a brief how-to guide on cognitive mapping using SEEG; and Dr Alena Stasenko discussed the complexities of functional mapping of bilingual patients. We have included references for more detailed information on the content of our presentation.

Keywords: epilepsy surgery; fMRI; language mapping; memory mapping; stereoelectroencephalography.

PubMed Disclaimer

Conflict of interest statement

The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Hypothesis-driven map to guide electrode placement.
See this image and copyright information in PMC

References

    1. Hamberger MJ. Cortical language mapping in epilepsy: a critical review. Neuropsychol Rev. 2007;17:477–489. - PubMed
    1. Benjamin CF. Cognitive biomarkers in the clinic: lessons from presurgical fMRI. J Clin Neurophysiol. 2022;39(2):121–128. - PubMed
    1. Bearden DJ, Ehrenberg A, Selawski Ret al. Four-Way Wada: SEEG-based mapping with electrical stimulation, high frequency activity, and phase amplitude coupling to complement traditional Wada and functional MRI prior to epilepsy surgery. Epilepsy Res. 2023;192:1–5. - PMC - PubMed
    1. Loring DW. History of neuropsychology through epilepsy eyes. Arch Clin Neuropsychol. 2010;25(4):259–273. - PMC - PubMed
    1. Boas WE. Juhn A. Wada and the sodium amytal test the first (and last?) 50 years. J Hist Neurosci. 1999;8(3):286–292. - PubMed

LinkOut - more resources