Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Nov 6;10(21):e40191.
doi: 10.1016/j.heliyon.2024.e40191. eCollection 2024 Nov 15.

Association analyses of nutritional markers with Parkinson's disease and Alzheimer's disease

Dong-Juan Xu  1 , Yi-Lei Shen  1 , Meng-Meng Hu  1 , Ling-Ling Li  1 , Yuan Fang  1 , Ju-Ping He  1 , Lu-Lu Ma  2 , Shan-Shan Xu  2 , Jian-Yong Wang  2
Affiliations

Association analyses of nutritional markers with Parkinson's disease and Alzheimer's disease

Dong-Juan Xu et al. Heliyon. .

Abstract

Introduction: Parkinson's disease (PD) and Alzheimer's disease (AD) are common neurodegenerative diseases with multifaceted etiology. Nutritional and metabolic abnormalities are frequently implicated in PD and AD. In this observational study, we analyzed a series of nutritional markers, and aimed to understand their association with AD and PD risk.

Methods: A total of 424 PD patients, 314 AD patients, and 388 healthy controls were included. Nutritional markers including Hemoglobin A1c, vitamin B12, folate, apolipoprotein B (ApoB), apolipoprotein A1 (ApoA1), low-density lipoprotein (LDL), high-density lipoprotein, triglyceride, total cholesterol (TC), uric acid and homocysteine (HCY) were measured. Significance for odds ratios examining was P < 0.0045 after bonferroni correction.

Results: Multifactor risk analysis showed that ApoB, LDL, and TC reduce PD risk, while HCY increase PD risk. ApoA1 and HCY are protective and risk factors for AD, respectively.

Conclusion: The cross-sectional study demonstrates that HCY and lipid metabolism markers are associated with PD and AD risks. Our findings support the involvement of one-carbon metabolism and lipid metabolism disturbance in PD and AD.

Keywords: Alzheimer’s disease; Apolipoprotein; Homocysteine; Lipid; Parkinson’s disease.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Similar articles

See all similar articles

References

    1. Cui L., Hou N.N., Wu H.M., Zuo X., Lian Y.Z., Zhang C.N., et al. Prevalence of alzheimer's disease and Parkinson's disease in China: an updated systematical analysis. Front. Aging Neurosci. 2020;12 doi: 10.3389/fnagi.2020.603854. - DOI - PMC - PubMed
    1. Kalia L.V., Lang A.E. Parkinson's disease. Lancet. 2015;386:896–912. doi: 10.1016/S0140-6736(14)61393-3. - DOI - PubMed
    1. Scheltens P., Blennow K., Breteler M.M., de Strooper B., Frisoni G.B., Salloway S., et al. Alzheimer's disease. Lancet. 2016;388:505–517. doi: 10.1016/S0140-6736(15)01124-1. - DOI - PubMed
    1. McCulloch C.C., Kay D.M., Factor S.A., Samii A., Nutt J.G., Higgins D.S., et al. Exploring gene-environment interactions in Parkinson's disease. Hum. Genet. 2008;123:257–265. doi: 10.1007/s00439-008-0466-z. - DOI - PubMed
    1. Marras C., Goldman S.M. Genetics meets environment: evaluating gene-environment interactions in neurologic diseases. Semin. Neurol. 2011;31:553–561. doi: 10.1055/s-0031-1299793. - DOI - PubMed

LinkOut - more resources