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Case Reports
. 1986 Apr;77(4):635-9.
doi: 10.1016/0091-6749(86)90358-1.

Occupational asthma caused by cellulase

E Losada, M Hinojosa, I Moneo, J Dominguez, M L Diez Gomez, M D Ibañez
Case Reports

Occupational asthma caused by cellulase

E Losada et al. J Allergy Clin Immunol. 1986 Apr.

Abstract

Inhalation of enzyme dusts can cause occupational asthma, and the list of enzymes able to induce asthma is increasing. We report two patients with asthma induced by occupational exposure to cellulase powder derived from Aspergillus niger. A type I hypersensitivity to this enzyme was demonstrated by means of skin test reactivity, positive passive transfer test, positive reverse enzyme immunoassay for specific IgE, and immediate bronchial provocation test response to cellulase dust. Skin tests with an A. niger extract were positive. Cross-reactivity between cellulase dust and an entire A. niger extract was also demonstrated.

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