S2k guideline basal cell carcinoma of the skin (update 2023)

doi:10.1111/ddg.15566

Practice Guideline

. 2024 Dec;22(12):1697-1714.

doi: 10.1111/ddg.15566. Epub 2024 Nov 25.

S2k guideline basal cell carcinoma of the skin (update 2023)

Berenice M Lang¹, Panagiotis Balermpas², Andrea Bauer³, Andreas Blum⁴, Thomas Dirschka^{5

6}, Markus Follmann⁷, Jorge Frank⁸, Bernhard Frerich⁹, Klaus Fritz¹⁰, Axel Hauschild¹¹, Ludwig M Heindl¹², Hans-Peter Howaldt¹³, Stephan Ihrler¹⁴, Vinodh Kakkassery¹⁵, Bernhard Klumpp^{16

17}, Albrecht Krause-Bergmann¹⁸, Christoph Löser¹⁹, Markus Meissner²⁰, Michael M Sachse²¹, Max Schlaak²², Michael P Schön⁸, Lutz Tischendorf²³, Michael Tronnier²⁴, Dirk Vordermark²⁵, Julia Welzel²⁶, Michael Weichenthal¹¹, Susanne Wiegand²⁷, Roland Kaufmann²⁸, Stephan Grabbe¹

Affiliations

¹ Department of Dermatology, Mainz University Medical Center, Mainz, Germany.
² Department of Radiation Oncology, University Hospital Zürich, Zürich, Switzerland.
³ Department of Dermatology, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany.
⁴ Dermatology and Teaching Office, Konstanz, Germany.
⁵ CentroDerm, Wuppertal, Germany.
⁶ Faculty of Health, University of Witten-Herdecke, Witten, Germany.
⁷ German Cancer Society, Berlin, Germany.
⁸ Department of Dermatology, Venereology and Allergology, Göttingen University Medical Center, Göttingen, Germany.
⁹ Department of Oral and Maxillofacial Plastic Surgery, Rostock University Medical Center, Rostock, Germany.
¹⁰ Dermatology and Laser Center, Landau, Germany.
¹¹ Department of Dermatology, Venereology and Allergology, University Hospital Schleswig-Holstein, Campus Kiel, Germany.
¹² Department of Ophthalmology, Cologne University Medical Center, Cologne, Germany.
¹³ Department of Oral and Maxillofacial Plastic Surgery, Gießen University Medical Center, Gießen, Germany.
¹⁴ Laboratory for Dermatohistology and Oral Pathology, Munich, Germany.
¹⁵ Department of Ophthalmology, Chemnitz Medical Center, Chemnitz, Germany.
¹⁶ Department of Diagnostic and Interventional Radiology, Tübingen University Medical Center, Tübingen, Germany.
¹⁷ Department of Radiology, Rems-Murr Medical Center, Winnenden, Germany.
¹⁸ Department of Plastic and Aesthetic Surgery, Gütersloh Medical Center, Germany.
¹⁹ Department of Dermatology, Skin Tumor Center, Ludwigshafen Medical Center, Ludwigshafen, Germany.
²⁰ Dermatology Wiesbaden, Wiesbaden, Germany.
²¹ Department of Dermatology, Allergology and Phlebology, Bremerhaven Medical Center, Bremerhaven, Germany.
²² Department of Dermatology, Venereology and Allergology, Skin Tumor Center, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
²³ Oral and Maxillofacial Surgery Office, Halle, Germany.
²⁴ Department of Dermatology, Venereology and Allergology, Helios Medical Center, Hildesheim, Germany.
²⁵ Department of Radiation Oncology, Halle University Medical Center, Martin Luther University Halle-Wittenberg, Halle, Germany.
²⁶ Department of Dermatology and Allergology, Augsburg University Medical Center, Augsburg, Germany.
²⁷ Department of Otorhinolaryngology, Leipzig University Medical Center, Leipzig, Germany.
²⁸ Department of Dermatology, Venereology and Allergology, Frankfurt University Medical Center, Frankfurt, Germany.

PMID: 39584658
PMCID: PMC11626229
DOI: 10.1111/ddg.15566

Practice Guideline

S2k guideline basal cell carcinoma of the skin (update 2023)

Berenice M Lang et al. J Dtsch Dermatol Ges. 2024 Dec.

. 2024 Dec;22(12):1697-1714.

doi: 10.1111/ddg.15566. Epub 2024 Nov 25.

Authors

Affiliations

¹ Department of Dermatology, Mainz University Medical Center, Mainz, Germany.
² Department of Radiation Oncology, University Hospital Zürich, Zürich, Switzerland.
³ Department of Dermatology, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany.
⁴ Dermatology and Teaching Office, Konstanz, Germany.
⁵ CentroDerm, Wuppertal, Germany.
⁶ Faculty of Health, University of Witten-Herdecke, Witten, Germany.
⁷ German Cancer Society, Berlin, Germany.
⁸ Department of Dermatology, Venereology and Allergology, Göttingen University Medical Center, Göttingen, Germany.
⁹ Department of Oral and Maxillofacial Plastic Surgery, Rostock University Medical Center, Rostock, Germany.
¹⁰ Dermatology and Laser Center, Landau, Germany.
¹¹ Department of Dermatology, Venereology and Allergology, University Hospital Schleswig-Holstein, Campus Kiel, Germany.
¹² Department of Ophthalmology, Cologne University Medical Center, Cologne, Germany.
¹³ Department of Oral and Maxillofacial Plastic Surgery, Gießen University Medical Center, Gießen, Germany.
¹⁴ Laboratory for Dermatohistology and Oral Pathology, Munich, Germany.
¹⁵ Department of Ophthalmology, Chemnitz Medical Center, Chemnitz, Germany.
¹⁶ Department of Diagnostic and Interventional Radiology, Tübingen University Medical Center, Tübingen, Germany.
¹⁷ Department of Radiology, Rems-Murr Medical Center, Winnenden, Germany.
¹⁸ Department of Plastic and Aesthetic Surgery, Gütersloh Medical Center, Germany.
¹⁹ Department of Dermatology, Skin Tumor Center, Ludwigshafen Medical Center, Ludwigshafen, Germany.
²⁰ Dermatology Wiesbaden, Wiesbaden, Germany.
²¹ Department of Dermatology, Allergology and Phlebology, Bremerhaven Medical Center, Bremerhaven, Germany.
²² Department of Dermatology, Venereology and Allergology, Skin Tumor Center, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
²³ Oral and Maxillofacial Surgery Office, Halle, Germany.
²⁴ Department of Dermatology, Venereology and Allergology, Helios Medical Center, Hildesheim, Germany.
²⁵ Department of Radiation Oncology, Halle University Medical Center, Martin Luther University Halle-Wittenberg, Halle, Germany.
²⁶ Department of Dermatology and Allergology, Augsburg University Medical Center, Augsburg, Germany.
²⁷ Department of Otorhinolaryngology, Leipzig University Medical Center, Leipzig, Germany.
²⁸ Department of Dermatology, Venereology and Allergology, Frankfurt University Medical Center, Frankfurt, Germany.

PMID: 39584658
PMCID: PMC11626229
DOI: 10.1111/ddg.15566

Abstract

Basal cell carcinoma is the most common malignant tumor in the fair-skinned population and its incidence continues to rise. An update of the S2k guideline with the participation of all specialist societies familiar with the clinical picture and previous literature research is of great importance for the quality of care for affected patients. In addition to epidemiology, diagnostics and histology are discussed. After risk stratification, therapy is divided into topical, systemic and radiation therapy. Surgical removal remains the treatment of first choice in most cases. The approval of anti-PD1 inhibitors for locally advanced and metastatic tumors has opened up a new option in second-line therapy (after hedgehog inhibitors).

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Conflict of interest statement

Please refer to the AWMF guideline report available online.

Figures

**FIGURE 1**
Therapy algorithm for the treatment of BCC., , , ,

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Cited by

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References

1. Lomas A, Leonardi‐Bee J, Bath‐Hextall F. A systematic review of worldwide incidence of nonmelanoma skin cancer. Br J Dermatol 2012; 166: 1069‐80 - PubMed
1. Peterson SC, Eberl M, Vagnozzi AN, et al. Basal cell carcinoma preferentially arises from stem cells within hair follicle and mechanosensory niches. Cell Stem Cell 2015; 16:400‐12 - PMC - PubMed
1. Kossard S, Epstein EH, Cerio J, et al. Basal cell carcinoma. In: LeBoit PE, Burg G, Weedon D, Sarasin A: Skin Tumours: Pathology and Genetics. World Health Organization Classification of Tumours. IARC Press, 2006; 13‐20
1. Krebs in Deutschland für 2013/2014. 11. Ausgabe. Robert Koch‐Institut (Hrsg) und die Gesellschaft der epidemiologischen Krebsregister in Deutschland e.V. (Hrsg). Berlin, 2017. (DOI: 10.17886/rkipubl-2017-007) - DOI
1. Krebsregister RLP Bericht 2017: Nicht‐melanozytäre Hauttumore (C44), https://www.krebsregister‐rlp.de/fileadmin/user_upload/C44_2017.pdf “accessed on December 1, 2023“

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[1] Lomas A, Leonardi‐Bee J, Bath‐Hextall F. A systematic review of worldwide incidence of nonmelanoma skin cancer. Br J Dermatol 2012; 166: 1069‐80 - PubMed

[2] Lomas A, Leonardi‐Bee J, Bath‐Hextall F. A systematic review of worldwide incidence of nonmelanoma skin cancer. Br J Dermatol 2012; 166: 1069‐80 - PubMed

[3] Peterson SC, Eberl M, Vagnozzi AN, et al. Basal cell carcinoma preferentially arises from stem cells within hair follicle and mechanosensory niches. Cell Stem Cell 2015; 16:400‐12 - PMC - PubMed

[4] Peterson SC, Eberl M, Vagnozzi AN, et al. Basal cell carcinoma preferentially arises from stem cells within hair follicle and mechanosensory niches. Cell Stem Cell 2015; 16:400‐12 - PMC - PubMed

[5] Kossard S, Epstein EH, Cerio J, et al. Basal cell carcinoma. In: LeBoit PE, Burg G, Weedon D, Sarasin A: Skin Tumours: Pathology and Genetics. World Health Organization Classification of Tumours. IARC Press, 2006; 13‐20

[6] Kossard S, Epstein EH, Cerio J, et al. Basal cell carcinoma. In: LeBoit PE, Burg G, Weedon D, Sarasin A: Skin Tumours: Pathology and Genetics. World Health Organization Classification of Tumours. IARC Press, 2006; 13‐20

[7] Krebs in Deutschland für 2013/2014. 11. Ausgabe. Robert Koch‐Institut (Hrsg) und die Gesellschaft der epidemiologischen Krebsregister in Deutschland e.V. (Hrsg). Berlin, 2017. (DOI: 10.17886/rkipubl-2017-007) - DOI

[8] Krebs in Deutschland für 2013/2014. 11. Ausgabe. Robert Koch‐Institut (Hrsg) und die Gesellschaft der epidemiologischen Krebsregister in Deutschland e.V. (Hrsg). Berlin, 2017. (DOI: 10.17886/rkipubl-2017-007) - DOI

[9] Krebsregister RLP Bericht 2017: Nicht‐melanozytäre Hauttumore (C44), https://www.krebsregister‐rlp.de/fileadmin/user_upload/C44_2017.pdf “accessed on December 1, 2023“

[10] Krebsregister RLP Bericht 2017: Nicht‐melanozytäre Hauttumore (C44), https://www.krebsregister‐rlp.de/fileadmin/user_upload/C44_2017.pdf “accessed on December 1, 2023“

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S2k guideline basal cell carcinoma of the skin (update 2023)

Affiliations

S2k guideline basal cell carcinoma of the skin (update 2023)

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Conflict of interest statement

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