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. 2024 Nov 22:58:e20230336.
doi: 10.1590/1980-220X-REEUSP-2023-0336en. eCollection 2024.

Association between chronic health conditions and severe acute respiratory syndrome in pregnant women: an exploratory study

[Article in English, Portuguese]
José Cláudio Garcia Lira Neto  1 , Márcio Flávio Moura de Araújo  2 , Flavia Paula Magalhães Monteiro  3 , Roberto Wagner Júnior Freire de Freitas  2 , Carla Regina de Sousa Teixeira  4 , Floriacy Stabnow Santos  5 , Ana Cristina Pereira de Jesus Costa  5 , Marcelino Santos Neto  5 , Lívia Maia Pascoal  5
Affiliations

Association between chronic health conditions and severe acute respiratory syndrome in pregnant women: an exploratory study

[Article in English, Portuguese]
José Cláudio Garcia Lira Neto et al. Rev Esc Enferm USP. .

Abstract
in English, Spanish

Objective: To analyze the association between chronic health conditions and severe acute respiratory syndrome in pregnant women.

Method: Retrospective, exploratory study conducted with 1,152 pregnant women from all 27 states of Brazil who sought hospital treatment and were diagnosed with severe acute respiratory syndrome between 2020 and 2022. Public data from the Influenza Epidemiological Surveillance Information System (SIVEP-Gripe) of the Brazilian Ministry of Health were used. Nonparametric tests were performed in data interpretation.

Results: The mortality rate of pregnant women due to severe acute respiratory syndrome in Brazil was 7%. Severe acute respiratory syndrome was statistically associated with the previous presence of diabetes (p = 0.023), neurological disease (p = 0.001), and drug use (p = 0.001). The epidemiological investigation of respiratory syndrome cases took longer in Black pregnant women (p = 0.012), unvaccinated women (p < 0.001) and women living in the north and south of the country (p = 0.011).

Conclusion: Severe acute respiratory syndrome was more common in pregnant women with diabetes, neurological disease and drug users. However, these conditions did not lead to an increase in the number of deaths.

Objetivo:: Analizar la asociación entre condiciones crónicas de salud y síndrome respiratorio agudo severo en mujeres embarazadas.

Método:: Estudio exploratorio retrospectivo realizado con 1.152 mujeres embarazadas de los 27 estados de Brasil que buscaron tratamiento hospitalario y fueron diagnosticadas con síndrome respiratorio agudo severo entre 2020 y 2022. Se utilizaron datos públicos del Sistema de Información de Vigilancia Epidemiológica de la Influenza (SIVEP-Gripe) del Ministerio de Salud de Brasil. Se realizaron pruebas no paramétricas en la interpretación de los datos.

Resultados:: La tasa de mortalidad de mujeres embarazadas por síndrome respiratorio agudo severo en Brasil fue del 7%. El síndrome respiratorio agudo severo se asoció estadísticamente con la presencia previa de diabetes (p = 0,023), enfermedad neurológica (p = 0,001) y uso de drogas (p = 0,001). La investigación epidemiológica de los casos de síndrome respiratorio agudo severo fue más prolongada en las embarazadas de raza negra (p = 0,012), las no vacunadas (p < 0,001) y las residentes en el norte y sur del país (p = 0,011).

Conclusión:: El síndrome respiratorio agudo severo fue más frecuente en las embarazadas con diabetes, enfermedades neurológicas y usuarias de drogas. Sin embargo, estas condiciones no provocaron un aumento en el número de muertes.

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Figures

Figure 1
Figure 1. Length of hospital stay due to SARS in pregnant women according to COVID-19 vaccination status. Brazil, 2023.
Figura 1
Figura 1. Período de internação por SRAG em gestantes segundo situação vacinal contra COVID-19. Brasil, 2023.
See this image and copyright information in PMC

References

    1. Brioschi Dos Santos AP, Vicente CR, Cola JP, Tanaka LF, Garbin JRT, Dell’Antonio LS, et al. The impact of COVID-19 on maternal death and fetal death, a cohort study in Brazil. PLoS One. 2023;18(8):e0290343. doi: 10.1371/journal.pone.0290343. - DOI - PMC - PubMed
    1. Carvalho-Sauer R, Flores-Ortiz R, Costa MCN, Teixeira MG, Saavedra R, Niag M, et al. Fetal death as an outcome of acute respiratory distress in pregnancy, during the COVID-19 pandemic: a population-based cohort study in Bahia, Brazil. BMC Pregnancy Childbirth. 2023;23(1):320. doi: 10.1186/s12884-023-05601-w. - DOI - PMC - PubMed
    1. Alzamora MC, Paredes T, Caceres D, Webb CM, Valdez LM, La Rosa M. Severe COVID-19 during pregnancy and possible vertical transmission. Am J Perinatol. 2020;37(8):861–865. doi: 10.1055/s-0040-1710050. - DOI - PMC - PubMed
    1. Kayem G, Lecarpentier E, Deruelle P, Bretelle F, Azria E, Blanc J, et al. A snapshot of the Covid-19 pandemic among pregnant women in France. J Gynecol Obstet Hum Reprod. 2020;49(7):101826. doi: 10.1016/j.jogoh.2020.101826. - DOI - PMC - PubMed
    1. Takemoto MLS, Nakamura-Pereira M, Menezes MO, Katz L, Knobel R, Amorim MMR, et al. Higher case fatality rate among obstetric patients with COVID-19 in the second year of pandemic in Brazil: do new genetic variants play a role? medRxiv. 2021 doi: 10.1101/2021.05.06.21256651. - DOI

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