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Review
. 2024 Oct 25;16(6):1214-1222.
doi: 10.3390/neurolint16060092.

Chronic Immune Sensory Polyradiculopathy (CISP): A Systematic Review of the Literature

Saurabh Singhal  1 , Rahul Khanna  2 , Anudeep Surendranath  3 , Jayksh Chhabra  4 , Vismay Thakkar  5 , Rajesh Gupta  4
Affiliations
Review

Chronic Immune Sensory Polyradiculopathy (CISP): A Systematic Review of the Literature

Saurabh Singhal et al. Neurol Int. .

Abstract

Chronic immune sensory polyradiculopathy (CISP) is a rare inflammatory immune disorder affecting the nervous system, primarily targeting the proximal sensory nerve roots. The condition was first described by Sinreich in 2004. We conducted a systematic review of CISP cases published on PubMed to identify common clinical presentations, along with neurophysiological, radiological, cerebrospinal fluid (CSF), and other findings. Our review included a total of 22 patients from 8 articles. Many patients presented with gait difficulties and sensory ataxia and were found to have normal nerve conduction studies (NCS) and electromyography (EMG) but exhibited characteristic abnormalities in somatosensory evoked potentials (SSEP), elevated CSF protein levels, thickened nerve roots on contrast-enhanced lumbar spine MRIs, and histological changes on nerve root biopsies. Clinical improvement was observed following treatment with steroids and/or intravenous immunoglobulin (IVIG). The study concluded that while CISP is rare, it is an important clinical entity to consider, as accurate diagnosis and appropriate treatment can lead to significant improvements in neurological symptoms and disabilities.

Keywords: AIDP; CIDP; CISP; SSEP; ataxia; chronic immune sensory polyradiculopathy.

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Conflict of interest statement

Author Rahul Khanna was employed by the company Neurology and Sleep Clinic, PLC. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
PRISMA table for the literature review.
See this image and copyright information in PMC

References

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