Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Nov 25;26(1):5.
doi: 10.1007/s10048-024-00793-5.

Epigenetic dysregulation in glioblastoma: potential pathways to precision medicine

Vijeta Prakash  1 , Reema Gabrani  2
Affiliations
Review

Epigenetic dysregulation in glioblastoma: potential pathways to precision medicine

Vijeta Prakash et al. Neurogenetics. .

Abstract

The emerging field of epigenetics has been driving glioblastoma multiforme (GBM) development and progression. Various epigenetic alterations involving tumor suppressor genes, oncogenes, and signaling pathways have been identified in GBM. These alterations contribute to the aggressive behavior, therapeutic resistance, and tumor heterogeneity observed in GBM. Furthermore, the identification of specific genetic mutations associated with epigenetic dysregulation in GBM has provided new insights into the molecular subtypes and potential therapeutic targets within GBM. Understanding the complex interplay between genetic and epigenetic alterations in GBM is crucial for the development of effective and personalized therapies for this devastating disease. This review paper provides an overview of the epigenetic changes occurring in GBM and the potential of targeted epigenetic therapies as a promising avenue for GBM treatment, highlighting the challenges and future directions in this field has been deliberated.

Keywords: DNA methylation; Epigenetic-based therapy; Gene silencing; Histone modification; Inhibitors.

PubMed Disclaimer

Conflict of interest statement

Declarations. Competing interests: The authors declare no competing interests.

Similar articles

See all similar articles

Cited by

References

    1. Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D, Ellison DW (2021) The 2021 WHO classification of tumors of the central nervous system: a summary. Neuro-oncol 23(8):1231–1251. https://doi.org/10.1093/neuonc/noab106 - DOI - PubMed - PMC
    1. American Association of Neurological Surgeons (2023) Glioblastoma Multiforme. https://www.aans.org/en/Patients/Neurosurgical-Conditions-and-Treatments... (accessed 17 October 2023)
    1. Waddington CH (2016) An introduction to modern genetics. Routledge
    1. Zhang Y, Cruickshanks N, Pahuski M, Yuan F, Dutta A, Schiff D, Abounader R (2017) Noncoding RNAs in glioblastoma. Exon Publications 95–130. https://doi.org/10.15586/codon.glioblastoma.2017.ch6
    1. Klughammer J, Kiesel B, Roetzer T, Fortelny N, Nemc A, Nenning KH, Bock C (2018) The DNA methylation landscape of glioblastoma disease progression shows extensive heterogeneity in time and space. Nat Med 24(10):1611–1624. https://doi.org/10.1038/s41591-018-0156-x - DOI - PubMed - PMC

LinkOut - more resources