Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2025:2877:25-43.
doi: 10.1007/978-1-0716-4256-6_2.

Marburg Virus Medical Countermeasures

Karen A Martins  1 , Daniel N Wolfe  2
Affiliations
Review

Marburg Virus Medical Countermeasures

Karen A Martins et al. Methods Mol Biol. 2025.

Abstract

Among the Filoviridae, Marburg virus (MARV) is a biological threat for which no licensed vaccines or therapeutics are currently available. In contrast, we have licensed products for Ebola virus (EBOV), another member of the Filoviridae family. The availability of licensed medical countermeasures (MCMs) for EBOV provides an opportunity to test a key objective of many pandemic preparedness plans, which is to apply some of the same technological approaches demonstrated to be successful for one agent, EBOV, to a second agent, MARV. This chapter will discuss (1) lessons learned from EBOV outbreak responses and MCM development that are applicable to MARV MCM development, (2) the likely concept of operations for using vaccines and therapeutics against MARV, and (3) target product profiles based on the concept of operations. Finally, we will discuss the current status of the MCM pipeline for MARV and next steps to advance these countermeasures to licensure.

Keywords: Antibodies; Clinical trials; Filovirus; MARV; Therapeutic; Vaccine.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. CDC (2023) Marburg virus disease outbreaks. 2023 [cited 2023 8/22/2023]. Available from: https://www.cdc.gov/vhf/marburg/outbreaks/chronology.html
    1. Amman BR, Bird BH, Bakarr IA, Bangura J, Schuh AJ et al (2020) Isolation of Angola-like Marburg virus from Egyptian rousette bats from West Africa. Nat Commun 11(1):510 - DOI - PubMed - PMC
    1. Towner JS, Amman BR, Sealy TK, Reeder Carroll SA, Comer JA et al (2009) Isolation of genetically diverse Marburg viruses from Egyptian fruit bats. PLoS Pathog 5(7):e1000536 - DOI - PubMed - PMC
    1. Schindell BG, Webb AL, Kindrachuk J (2018) Persistence and sexual transmission of filoviruses. Viruses 10(12):683 - DOI - PubMed - PMC
    1. Henao-Restrepo AM, Camacho A, Longini IM, Watson CH, Edmunds WJ, Egger M et al (2017) Efficacy and effectiveness of an rVSV-vectored vaccine in preventing Ebola virus disease: final results from the Guinea ring vaccination, open-label, cluster-randomised trial (Ebola Ça Suffit!). Lancet 389:P505–P518 - DOI

MeSH terms

LinkOut - more resources