Inhaled nitric oxide clinical confusions: population types, duration, and responsiveness

Affiliations

¹ Department of Critical Care Medicine, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Xuhui District, Shanghai, 200032, China.
² Department of Critical Care Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China. sucapter@gmail.com.
³ Department of Critical Care Medicine, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Xuhui District, Shanghai, 200032, China. ju.minjie@zs-hospital.sh.cn.

^# Contributed equally.

Comment

Kai Liu et al. Crit Care. 2024.

. 2024 Nov 25;28(1):384.

doi: 10.1186/s13054-024-05181-x.

¹ Department of Critical Care Medicine, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Xuhui District, Shanghai, 200032, China.
² Department of Critical Care Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China. sucapter@gmail.com.
³ Department of Critical Care Medicine, Zhongshan Hospital, Fudan University, No. 180 Fenglin Road, Xuhui District, Shanghai, 200032, China. ju.minjie@zs-hospital.sh.cn.

^# Contributed equally.

No abstract available

Conflict of interest statement

Declarations. Ethics approval and consent to participate: Not applicable. Competing interests: The authors declare no competing interests.

Impact of low dose inhaled nitric oxide treatment in spontaneously breathing and intubated COVID-19 patients: a retrospective propensity-matched study.
Isha S, Balasubramanian P, Hanson AJ, Jonna S, Raavi L, Khadka S, Vasudhar A, Sinclair De Frias J, Jenkins A, Balavenkataraman A, Tekin A, Bansal V, Reddy S, Caples SM, Khan SA, Jain NK, LaNou AT, Kashyap R, Cartin-Ceba R, Milian RD, Venegas CP, Shapiro AB, Bhattacharyya A, Chaudhary S, Kiley SP, Quinones QJ, Patel NM, Guru PK, Moreno Franco P, Sanghavi DK. Isha S, et al. Crit Care. 2024 Oct 25;28(1):344. doi: 10.1186/s13054-024-05093-w. Crit Care. 2024. PMID: 39456071 Free PMC article.

1. Liu K, Wang H, Yu SJ, et al. Inhaled pulmonary vasodilators: a narrative review. Ann Transl Med. 2021;9(7):597. - PMC - PubMed
1. Isha S, Balasubramanian P, Hanson AJ, et al. Impact of low dose inhaled nitric oxide treatment in spontaneously breathing and intubated COVID-19 patients: a retrospective propensity-matched study. Crit Care. 2024;28(1):344. - PMC - PubMed
1. Griffiths MJ, Evans TW. Inhaled nitric oxide therapy in adults. N Engl J Med. 2005;353(25):2683–95. - PubMed
1. Shetty NS, Giammatteo V, Gaonkar M, et al. Differences in the response to high-dose inhaled nitric oxide in self-identified black and white individuals: a Post Hoc analysis of the NOSARSCOVID randomized clinical trial. Am J Respir Crit Care Med. 2024;209(7):887–90. - PMC - PubMed
1. Gerlach H, Keh D, Semmerow A, et al. Dose-response characteristics during long-term inhalation of nitric oxide in patients with severe acute respiratory distress syndrome: a prospective, randomized, controlled study. Am J Respir Crit Care Med. 2003;167(7):1008–15. - PubMed