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Review
. 2024 Nov 19;19(1):20241041.
doi: 10.1515/med-2024-1041. eCollection 2024.

Utilizing reactive oxygen species-scavenging nanoparticles for targeting oxidative stress in the treatment of ischemic stroke: A review

Lingmin Shao  1 , Can Wang  2 , Gang Xu  3 , Zewei Tu  4 , Xinyuan Yu  5 , Chao Weng  6 , Jia Liu  1 , Zhihong Jian  1
Affiliations
Review

Utilizing reactive oxygen species-scavenging nanoparticles for targeting oxidative stress in the treatment of ischemic stroke: A review

Lingmin Shao et al. Open Med (Wars). .

Abstract

Ischemic stroke, which accounts for the majority of stroke cases, triggers a complex series of pathophysiological events, prominently characterized by acute oxidative stress due to excessive production of reactive oxygen species (ROS). Oxidative stress plays a crucial role in driving cell death and inflammation in ischemic stroke, making it a significant target for therapeutic intervention. Nanomedicine presents an innovative approach to directly mitigate oxidative damage. This review consolidates existing knowledge on the role of oxidative stress in ischemic stroke and assesses the potential of various ROS-scavenging nanoparticles (NPs) as therapeutic agents. We explore the properties and mechanisms of metal, metal-oxide, and carbon-based NPs, emphasizing their catalytic activity and biocompatibility in scavenging free radicals and facilitating the delivery of therapeutic agents across the blood-brain barrier. Additionally, we address the challenges such as cytotoxicity, immunogenicity, and biodistribution that need to be overcome to translate these nanotechnologies from bench to bedside. The future of NP-based therapies for ischemic stroke holds promise, with the potential to enhance outcomes through targeted modulation of oxidative stress.

Keywords: ischemic stroke; nanoparticles; oxidative stress.

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Conflict of interest statement

Conflict of interest: Authors state no conflict of interest.

Figures

Figure 1
Figure 1
Mechanism of oxidative stress in IR injury.
Figure 2
Figure 2
Utilizing ROSscavenging NPs for the treatment of ischemic stroke.
See this image and copyright information in PMC

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