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. 2025 May 1;120(5):1140-1143.
doi: 10.14309/ajg.0000000000003235. Epub 2024 Nov 26.

Serum Gastrin Levels Are Associated With Prevalent Neuroendocrine Tumors in Autoimmune Metaplastic Atrophic Gastritis

Andre Jove  1 , Christina Lin  2 , Joo Ha Hwang  2 , Vidhya Balasubramanian  1 , Nielsen Q Fernandez-Becker  2 , Robert J Huang  2
Affiliations

Serum Gastrin Levels Are Associated With Prevalent Neuroendocrine Tumors in Autoimmune Metaplastic Atrophic Gastritis

Andre Jove et al. Am J Gastroenterol. .

Abstract

Introduction: Autoimmune metaplastic atrophic gastritis (AMAG) is a precancerous condition that predisposes to gastric neuroendocrine tumors (gNETs). There exist no methods to stratify patients with AMAG for gNET risk.

Methods: We identified a cohort of patients with AMAG within a university health system using histopathologic and serologic criteria. We analyzed features predictive of prevalent gNET.

Results: We identified 181 patients with AMAG and 41 (22.7%) with prevalent gNET. Gastrin levels were elevated in gNET (1,859.8 vs 679.5 pg/mL, P < 0.001), and gastrin titers demonstrated good discrimination (c = 0.799, 95% CI 0.707-0.892) for gNET.

Discussion: Gastrin levels differ significantly between patients with AMAG with and without gNET.

Keywords: autoimmune gastritis; biomarker; cancer surveillance; gastric neuroendocrine tumors.

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Conflict of interest statement

Disclosures: The authors declare no potential conflicts of interest with regards to this manuscript.

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