Is LPAR5 agonist a new treatment for microvilli inclusion disease?

C Chris Yun^{1

2}

Affiliations

¹ Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States.
² Gastroenterology Research, Atlanta Veterans Administration Medical Center, Decatur, Georgia, United States.

Editorial

C Chris Yun. Am J Physiol Gastrointest Liver Physiol. 2025.

. 2025 Jan 1;328(1):G49-G50.

doi: 10.1152/ajpgi.00355.2024. Epub 2024 Nov 26.

C Chris Yun^{1

2}

¹ Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States.
² Gastroenterology Research, Atlanta Veterans Administration Medical Center, Decatur, Georgia, United States.

No abstract available

Conflict of interest statement

Conflict of Interest

The author declares that no conflict of interest exists.

Alterations in cellular metabolic pathway and epithelial cell maturation induced by MYO5B defects are partially reversible by LPAR5 activation.
Momoh M, Rathan-Kumar S, Burman A, Brown ME, Adeniran F, Ramos C, Goldenring JR, Roland JT, Kaji I. Momoh M, et al. Am J Physiol Gastrointest Liver Physiol. 2024 Dec 1;327(6):G877-G899. doi: 10.1152/ajpgi.00091.2024. Epub 2024 Oct 15. Am J Physiol Gastrointest Liver Physiol. 2024. PMID: 39404772 Free PMC article.

1. Erickson RP, Larson-Thome K, Valenzuela RK, Whitaker SE, and Shub MD. Navajo microvillous inclusion disease is due to a mutation in MYO5B. Am J Med Genet A 146A: 3117–3119, 2008. - PubMed
1. Engevik AC, Kaji I, Engevik MA, Meyer AR, Weis VG, Goldstein A, Hess MW, Muller T, Koepsell H, Dudeja PK, Tyska M, Huber LA, Shub MD, Ameen N, and Goldenring JR. Loss of MYO5B Leads to Reductions in Na(+) Absorption With Maintenance of CFTR-Dependent Cl(−) Secretion in Enterocytes. Gastroenterology 155: 1883–1897 e1810, 2018. - PMC - PubMed
1. Kaji I, Roland JT, Rathan-Kumar S, Engevik AC, Burman A, Goldstein AE, Watanabe M, and Goldenring JR. Cell differentiation is disrupted by MYO5B loss through Wnt/Notch imbalance. JCI Insight 6: 2021. - PMC - PubMed
1. Bowman DM, Kaji I, and Goldenring JR. Altered MYO5B Function Underlies Microvillus Inclusion Disease: Opportunities for Intervention at a Cellular Level. Cell Mol Gastroenterol Hepatol 2022. - PMC - PubMed
1. Lee SJ, Leoni G, Neumann PA, Chun J, Nusrat A, and Yun CC. Distinct phospholipase C-beta isozymes mediate lysophosphatidic acid receptor 1 effects on intestinal epithelial homeostasis and wound closure. Mol Cell Biol 33: 2016–2028, 2013. - PMC - PubMed