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Review
. 2024 Dec:100:101323.
doi: 10.1016/j.mam.2024.101323. Epub 2024 Nov 25.

Testicular immunity

Shu-Yun Li  1 , Sudeep Kumar  1 , Xiaowei Gu  1 , Tony DeFalco  2
Affiliations
Review

Testicular immunity

Shu-Yun Li et al. Mol Aspects Med. 2024 Dec.

Abstract

The testis is a unique environment where immune responses are suppressed to allow the development of sperm that possess autoimmunogenic antigens. There are several contributors responsible for testicular immune privilege, including the blood-testis barrier, testicular immune cells, immunomodulation by Sertoli cells, and high levels of steroid hormones. Despite multiple mechanisms in place to regulate the testicular immune environment, pathogens that disrupt testicular immunity can lead to long-term effects such as infertility. If testicular immunity is disturbed, autoimmune reactions can also occur, leading to aberrant immune cell infiltration and subsequent attack of autoimmunogenic germ cells. Here we discuss cellular and molecular factors underlying testicular immunity and how testicular infection or autoimmunity compromise immune privilege. We also describe infections and autoimmune diseases that impact the testis. Further research into testicular immunity will reveal how male fertility is maintained and will help update therapeutic strategies for infertility and other testicular disorders.

Keywords: Autoimmunity; Blood-testis barrier; Immune privilege; Infertility; Orchitis; Testicular immunity.

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References

    1. A SV, Dhama K, Chakraborty S, Samad HA, Latheef SK, Sharun K, Khurana SK, K A, Tiwari R, Bhatt P, K V, Chaicumpa W, 2019. Role of Antisperm Antibodies in Infertility, Pregnancy, and Potential forContraceptive and Antifertility Vaccine Designs: Research Progress and Pioneering Vision. Vaccines (Basel) 7 (3). - PMC - PubMed
    1. Abe T, Nishimura H, Sato T, Suzuki H, Ogawa T, Suzuki T, 2020. Transcriptome analysis reveals inadequate spermatogenesis and immediate radical immune reactions during organ culture in vitro spermatogenesis. Biochem Biophys Res Commun 530 (4), 732–738. - PubMed
    1. Adam M, Schwarzer JU, Köhn FM, Strauss L, Poutanen M, Mayerhofer A, 2011. Mast cell tryptase stimulates production of decorin by human testicular peritubular cells: possible role of decorin in male infertility by interfering with growth factor signaling. Hum Reprod 26 (10), 2613–2625. - PubMed
    1. Adam M, Urbanski HF, Garyfallou VT, Welsch U, Kohn FM, Ullrich Schwarzer J, Strauss L, Poutanen M, Mayerhofer A, 2012. High levels of the extracellular matrix proteoglycan decorin are associated with inhibition of testicular function. Int J Androl 35 (4), 550–561. - PMC - PubMed
    1. Agarwal A, Mulgund A, Hamada A, Chyatte MR, 2015. A unique view on male infertility around the globe. Reprod Biol Endocrinol 13, 37. - PMC - PubMed

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