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Review
. 2024 Nov 27;14(1):99.
doi: 10.1186/s13561-024-00584-6.

Economic burden of hepatitis B patients and its influencing factors in China: a systematic review

Mengxia Yan  1   2 , Huanhuan Ye  2 , Ying Chen  1 , Huajie Jin  3 , Han Zhong  4 , Bobo Pan  5 , Youqin Dai  5 , Bin Wu  6
Affiliations
Review

Economic burden of hepatitis B patients and its influencing factors in China: a systematic review

Mengxia Yan et al. Health Econ Rev. .

Abstract

Background & aim: Hepatitis B is globally recognized as a major public health problem that imposes a huge economic burden on society. China is a major country with hepatitis B infection; however, an updated overview of the economic burden of hepatitis B and related diseases in China has not been provided. This study aimed to provide a comprehensive understanding of the economic burden and factors influencing hepatitis B and related diseases by synthesizing the available evidence, with the aim of informing clinical treatment and health decisions.

Methods: Two researchers systematically searched relevant literature published in PubMed, Web of Science, China Knowledge Network, Wanfang Database, and Vip Database from 2002 to 2022, and conducted title and abstract reviews according to the PRISMA guidelines for the development of nerfing criteria, as well as quality evaluation of the included literature.

Results: Thirty-three studies were included in the literature. The quality of the included literature was average, with the majority being individual studies and a few group studies, which showed that the annual economic burden per capita of hepatitis B-related diseases was 92,978.34 RMB, with a high proportion of direct and hidden costs, and a large disparity in economic burden between related diseases, with the greatest burden for primary hepatocellular carcinoma and the smallest burden for acute hepatitis B. The study found that the main factors affecting the cost of disease were sex, age, occupational classification, place of residence, health insurance conditions, hospital class, length of hospitalization, use of antiviral drugs, comorbidities, and complications.

Conclusion: Hepatitis B has caused a huge economic burden on Chinese society, and hidden costs also respond to a great psychological burden on patients and their families. Based on existing studies, there is an urgent need for high-quality, multicenter, population-level studies to inform clinical treatment and health policy decisions.

Keywords: Direct costs; Economic burden; Hepatitis B; Implicit costs; Indirect costs; Systematic review Huanhuan Ye is the joint first author..

PubMed Disclaimer

Conflict of interest statement

Declarations. Conflict of interest: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as potential conflicts of interest.

Figures

Fig. 1
Fig. 1
Flow diagram
Fig. 2
Fig. 2
Volume of research literature by region
Fig. 3
Fig. 3
Average cost per time of hepatitis B and related patients. Abbreviations: AHB: Acute hepatitis B; CHB: Chronic hepatitis B; CLC: Compensated liver cirrhosis; DLC: Decompensated liver cirrhosis; SHB: Severe hepatitis B; PHC, primary hepatocellular carcinoma
Fig. 4
Fig. 4
Average annual cost of hepatitis B and related patients. Abbreviations: AHB: Acute hepatitis B; CHB: Chronic hepatitis B; CLC: Compensated liver cirrhosis; DLC: Decompensated liver cirrhosis; SHB: Severe hepatitis B; PHC, primary hepatocellular carcinoma
Fig. 5
Fig. 5
(a) Chart of direct costs as a percentage of each cost. (b) Average number of days of hospitalization for hepatitis B and related diseases. (c) Number of days patients missed work. (d) Number of days caregivers missed work
Fig. 6
Fig. 6
Average annual cost of patients with hepatitis B related diseases. Abbreviations: AHB: Acute hepatitis B; CHB: Chronic hepatitis B; CLC: Compensated liver cirrhosis; DLC: Decompensated liver cirrhosis; SHB: Severe hepatitis B; PHC, primary hepatocellular carcinoma
Fig. 7
Fig. 7
Average annual cost proportion chart
See this image and copyright information in PMC

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