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Review
. 2024 Nov 26;14(1):206.
doi: 10.1038/s41408-024-01191-8.

CAR-T cell therapy in Multiple Myeloma: current status and future challenges

Dawn Swan  1 , Deepu Madduri  2 , Jay Hocking  3
Affiliations
Review

CAR-T cell therapy in Multiple Myeloma: current status and future challenges

Dawn Swan et al. Blood Cancer J. .

Abstract

The treatment of multiple myeloma has changed dramatically in recent years, with huge strides forward made in the field. Chimeric antigen receptor T-cell therapy targeting the B cell maturation antigen (BCMA) is now widely approved in relapsed refractory patients and is moving into earlier treatment lines. In this review, we discuss the evidence underpinning current regulatory approvals and consider mechanisms through which CAR-T cell efficacy could be improved. These include tackling BCMA-loss, harnessing the immunosuppressive tumour microenvironment, manufacturing concerns including the potential role of other cellular sources, safety issues such as cytokine release syndrome and neurotoxicity, and optimal patient selection.

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Conflict of interest statement

Competing interests: DS: none; DM: Employment: Johnson and Johnson; JH: none.

Figures

Fig. 1
Fig. 1
Approach to improving CAR-T efficacy in Multiple Myeloma.
See this image and copyright information in PMC

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