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Review
. 2024 Nov 12;14(11):1436.
doi: 10.3390/biom14111436.

Organoids as Tools for Investigating Skin Aging: Mechanisms, Applications, and Insights

Xin-Yu Wang  1 , Qian-Nan Jia  1 , Jun Li  1 , He-Yi Zheng  1
Affiliations
Review

Organoids as Tools for Investigating Skin Aging: Mechanisms, Applications, and Insights

Xin-Yu Wang et al. Biomolecules. .

Abstract

Organoids have emerged as transformative tools in biomedical research, renowned for their ability to replicate the complexity construct of human tissues. Skin aging is a multifaceted biological process, influenced by both intrinsic factors and extrinsic factors. Traditional models for studying skin aging often fall short in capturing the intricate dynamics of human skin. In contrast, skin organoids offer a more physiologically relevant system, reflecting the structural and functional characteristics of native skin. These characteristics make skin organoids highly suitable for studying the mechanisms of skin aging, identifying novel therapeutic targets, and testing anti-aging interventions. Despite their promise, challenges such as limited scalability, reproducibility, and ethical considerations remain. Addressing these hurdles through interdisciplinary research and technological advancements will be essential to maximizing the potential of skin organoids for dermatological research and personalized anti-aging therapies.

Keywords: aging skin equivalent; aging skin organoid; in vitro skin models; skin aging; skin organoid.

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Conflict of interest statement

The authors declare no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1
Figure 1
Structure of skin tissue.
Figure 2
Figure 2
Brief mechanism of skin aging.
Figure 3
Figure 3
A schematic representation of the general process of skin organoid development from various sources of stem cells, viz., embryonic stem cells (ESCs), induced pluripotent cells (iPSCs), adult stem cells (ASCs), and cancer tissue cells in a culture media.
Figure 4
Figure 4
Applications of skin organoids: from culture to drug screening, aging research, and personalized medicine.
See this image and copyright information in PMC

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