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Review
. 2024 Nov 5;25(22):11893.
doi: 10.3390/ijms252211893.

Application of Fetal Membranes and Natural Materials for Wound and Tissue Repair

Marion Rouzaire  1 , Loïc Blanchon  2 , Vincent Sapin  2   3 , Denis Gallot  1   2
Affiliations
Review

Application of Fetal Membranes and Natural Materials for Wound and Tissue Repair

Marion Rouzaire et al. Int J Mol Sci. .

Abstract

The human fetal membrane is a globally accepted biological biomaterial for wound and tissue repair and regeneration in numerous fields, including dermatology, ophthalmology, and more recently orthopedics, maxillofacial and oral surgery, and nerve regeneration. Both cells and matrix components of amnion and chorion are beneficial, releasing a diverse range of growth factors, cytokines, peptides, and soluble extracellular matrix components. Beside fetal membranes, numerous natural materials have also been reported to promote wound healing. The biological properties of these materials may potentiate the pro-healing action of fetal membranes. Comparison of such materials with fetal membranes has been scant, and their combined use with fetal membranes has been underexplored. This review presents an up-to-date overview of (i) clinical applications of human fetal membranes in wound healing and tissue regeneration; (ii) studies comparing human fetal membranes with natural materials for promoting wound healing; and (iii) the literature on the combined use of fetal membranes and natural pro-healing materials.

Keywords: fetal membranes; natural materials; tissue repair; wound healing.

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Conflict of interest statement

The authors declare they have no conflicts of interest.

Figures

Figure 1
Figure 1
Structure of human fetal membranes. AEC: amniotic epithelial cells. Created in BioRender.
Figure 2
Figure 2
Pro-healing properties of human fetal membranes. Created in BioRender. Blanchon, L. (2024) BioRender.com/o54w144.
Figure 3
Figure 3
Selection of the reviews on fetal membrane applications for wound healing. In green, keywords used to build the equation; in red, explanation that articles from Medline and conference abstracts were excluded from Embase and Cochrane requests; in bold, number of articles eligible.
Figure 4
Figure 4
Reviews on applications of fetal membranes for wound healing.
Figure 5
Figure 5
Fetal membranes and natural materials used for tissue repair. AM: amniotic membrane; HA: hyaluronic acid; PDGF: platelet-derived growth factor. Created in BioRender. Blanchon, L. (2024) BioRender.com/s92f110.
See this image and copyright information in PMC

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