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Review
. 2024 Nov 14;25(22):12205.
doi: 10.3390/ijms252212205.

COVID-19 in Children and Vitamin D

Teodoro Durá-Travé  1   2 , Fidel Gallinas-Victoriano  2   3
Affiliations
Review

COVID-19 in Children and Vitamin D

Teodoro Durá-Travé et al. Int J Mol Sci. .

Abstract

In December 2019, the so-called "coronavirus disease 2019" (COVID-19) began. This disease is characterized by heterogeneous clinical manifestations, ranging from an asymptomatic process to life-threatening conditions associated with a "cytokine storm". This article (narrative review) summarizes the epidemiologic characteristics and clinical manifestations of COVID-19 and multi-system inflammatory syndrome in children (MIS-C). The effect of the pandemic confinement on vitamin D status and the hypotheses proposed to explain the age-related difference in the severity of COVID-19 are discussed. The role of vitamin D as a critical regulator of both innate and adaptive immune responses and the COVID-19 cytokine storm is analyzed. Vitamin D and its links to both COVID-19 (low levels of vitamin D appear to worsen COVID-19 outcomes) and the cytokine storm (anti-inflammatory activity) are detailed. Finally, the efficacy of vitamin D supplementation in COVID-19 is evaluated, but the evidence supporting vitamin D supplementation as an adjuvant treatment for COVID-19 remains uncertain.

Keywords: COVID-19; MIS-C; SARS-CoV-2 infection; vitamin D; vitamin D deficiency; vitamin D insufficiency; vitamin D supplementation.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Severity of illness in children with COVID-19.
See this image and copyright information in PMC

References

    1. Zhu N., Zhang D., Wang W., Li X., Yang B., Song J., Zhao X., Huang B., Shi W., Lu R., et al. A Novel Coronavirus from Patients with Pneumonia in China, 2019. N. Engl. J. Med. 2020;382:727–733. doi: 10.1056/NEJMoa2001017. - DOI - PMC - PubMed
    1. Zhang Y. The Epidemiological Characteristics of an Outbreak of 2019 Novel Coronavirus Diseases (COVID-19)—China, 2020. Chin. J. Epidemiol. 2020;2:113–122. - PMC - PubMed
    1. Rizzi M., Avellis V., Messina A., Germano C., Tavella E., Dodaro V., Vitale R., Revelli A., Zola P., Picone S., et al. Vitamin D Supplementation in Neonatal and Infant MIS-C Following COVID-19 Infection. Int. J. Mol. Sci. 2024;25:3712. doi: 10.3390/ijms25073712. - DOI - PMC - PubMed
    1. Zhao S., Zhuang Z., Ran J., Lin J., Yang G., Yang L., He D. The association between domestic train transportation and novel coronavirus (2019-nCoV) outbreak in China from 2019 to 2020: A data-driven correlational report. Travel. Med. Infect. Dis. 2020;33:101568. doi: 10.1016/j.tmaid.2020.101568. - DOI - PMC - PubMed
    1. Chung Y.S., Lam C.Y., Tan P.H., Tsang H.F., Wong S.C.C. Comprehensive Review of COVID-19: Epidemiology, Pathogenesis, Advancement in Diagnostic and Detection Techniques, and Post-Pandemic Treatment Strategies. Int. J. Mol. Sci. 2024;25:8155. doi: 10.3390/ijms25158155. - DOI - PMC - PubMed

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