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Review
. 2024 Nov 19;25(22):12409.
doi: 10.3390/ijms252212409.

The Interplay of Stress, Inflammation, and Metabolic Factors in the Course of Parkinson's Disease

Tal Ben Shaul  1   2 , Dan Frenkel  3   4 , Tanya Gurevich  1   2   4
Affiliations
Review

The Interplay of Stress, Inflammation, and Metabolic Factors in the Course of Parkinson's Disease

Tal Ben Shaul et al. Int J Mol Sci. .

Abstract

Parkinson's disease (PD) is a prevalent neurodegenerative condition for which there are symptomatic treatments but no disease-modifying therapies (DMTs). Extensive research over the years has highlighted the need for a multi-target DMT approach in PD that recognizes the various risk factors and their intricate interplay in contributing to PD-related neurodegeneration. Widespread risk factors, such as emotional stress and metabolic factors, have increasingly become focal points of exploration. Our review aims to summarize interactions between emotional stress and selected key players in metabolism, such as insulin, as potential mechanisms underlying neurodegeneration in PD.

Keywords: Parkinson’s disease; diabetes; dopaminergic degeneration; insulin signaling and resistance; metabolic factors; neurodegeneration; neuroinflammation; physiological stress; psychological stress.

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Conflict of interest statement

T.G. reports consultancy fees from Abbvie, Medison, Neuroderm, and Tradis Gat; travel support for her and her team from Alphamedix, Abbvie, and Medison; and grants from the International Parkinson Disease and Movement Disorders Society, Parkinson’s Foundation, and Tel Aviv University, outside of the present work. T.B.S. and D.F. have nothing to disclose.

Figures

Figure 1
Figure 1
Hypothetical role of stress as a trigger for metabolic changes and dopaminergic neurodegeneration in Parkinson’s disease (PD). Potential link between insulin signaling and stress in the progression of PD.
See this image and copyright information in PMC

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