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. 2024 Nov 14;14(11):1484.
doi: 10.3390/life14111484.

Impact of Multistrain Probiotic Supplementation on Glycemic Control in Type 2 Diabetes Mellitus-Randomized Controlled Trial

Venkata Chaithanya  1 , Janardanan Kumar  2 , Kakithakara Vajravelu Leela  1 , Mohan Ram  3 , Jayaprakash Thulukanam  1
Affiliations

Impact of Multistrain Probiotic Supplementation on Glycemic Control in Type 2 Diabetes Mellitus-Randomized Controlled Trial

Venkata Chaithanya et al. Life (Basel). .

Abstract

Hyperglycemia, a key characteristic of type 2 diabetes mellitus (T2DM), highlights the need for effective management strategies. This study aims to analyze the impact of multistrain probiotic supplementation on glycemic control in T2DM patients. During a 24-week randomized controlled trial involving 130 participants, subjects were assigned to either a probiotic group or a placebo group. The key outcomes included fasting blood glucose (FBG), postprandial blood glucose (PPBG), glycated hemoglobin (HbA1c) levels, and lipid profiles, assessed at baseline and post-intervention. The results indicated a significant reduction in HbA1c (p = 0.004) and increased HDL-c (p = 0.023) and improvements in lipid profiles in the probiotic group, alongside a trend toward decreased FBG and PPBG. No serious adverse effects were reported, indicating good tolerance of probiotics. These findings suggest that probiotics may positively influence metabolic parameters in T2DM patients, supporting their potential as a complementary dietary intervention. Further research is needed to understand the underlying mechanisms and enhance probiotic formulations for diabetic control.

Keywords: HbA1c; glycemic control; metabolic health; probiotics; type 2 diabetes.

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Conflict of interest statement

The authors declare no potential conflicts of interest.

Figures

Figure 1
Figure 1
CONSORT flowchart.
Figure 2
Figure 2
Analysis of (a) fasting blood glucose, (b) postprandial blood glucose, (c) total cholesterol, (d) triglycerides, (e) low-density lipoprotein cholesterol, and (f) very-low-density lipoprotein of placebo and probiotic group at 0th and 24th week. Data expressed in means.
Figure 2
Figure 2
Analysis of (a) fasting blood glucose, (b) postprandial blood glucose, (c) total cholesterol, (d) triglycerides, (e) low-density lipoprotein cholesterol, and (f) very-low-density lipoprotein of placebo and probiotic group at 0th and 24th week. Data expressed in means.
Figure 3
Figure 3
Analysis of (a) Hba1c and (b) HDL-c at baseline (pre) and at 24th week (post).
See this image and copyright information in PMC

References

    1. American Diabetes Association Standards of Care in Diabetes—2023 Abridged for Primary Care Providers. Clin. Diabetes. 2023;41:4–31. doi: 10.2337/cd23-as01. - DOI - PMC - PubMed
    1. Das T.K., Pradhan S., Chakrabarti S., Mondal K.C., Ghosh K. Current Status of Probiotic and Related Health Benefits. Appl. Food. Res. 2022;2:100185. doi: 10.1016/j.afres.2022.100185. - DOI
    1. Ballan R., Saad S.M.I. Characteristics of the Gut Microbiota and Potential Effects of Probiotic Supplements in Individuals with Type 2 Diabetes Mellitus. Foods. 2021;10:2528. doi: 10.3390/foods10112528. - DOI - PMC - PubMed
    1. Chaithanya V., Kumar J., Leela K.V., Angelin M., Satheesan A., Murugesan R. Metabolic Consequences of Alterations in Gut Microbiota Induced by Antidiabetic Medications. Diabetes Epidemiol. Manag. 2023;13:100180. doi: 10.1016/j.deman.2023.100180. - DOI
    1. Paquette S., Thomas S.C., Venkataraman K., Appanna V.D., Tharmalingam S. The Effects of Oral Probiotics on Type 2 Diabetes Mellitus (T2DM): A Clinical Trial Systematic Literature Review. Nutrients. 2023;15:4690. doi: 10.3390/nu15214690. - DOI - PMC - PubMed

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