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Review
. 2024 Nov 11;29(22):5316.
doi: 10.3390/molecules29225316.

How Do Cyclodextrins and Dextrans Affect the Gut Microbiome? Review of Prebiotic Activity

Anna Gościniak  1 , Emmanuelle Lainé  2 , Judyta Cielecka-Piontek  1
Affiliations
Review

How Do Cyclodextrins and Dextrans Affect the Gut Microbiome? Review of Prebiotic Activity

Anna Gościniak et al. Molecules. .

Abstract

The modulation of the gut microbiome through dietary components has garnered significant attention for its potential health benefits. Prebiotics, non-digestible food ingredients that promote the growth of beneficial gut bacteria, play a crucial role in maintaining gut health, enhancing immune function, and potentially preventing various metabolic and inflammatory disorders. This review explores the prebiotic activity of cyclodextrins and dextrans, focusing on their ability to influence gut microbiota composition and function. Both cyclodextrins and dextrans have demonstrated the capacity to promote the growth of beneficial bacterial populations, while also impacting short-chain fatty acid production, crucial for gut health.

Keywords: cyclodextrin; dextran; microbiome; prebiotics.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Scheme of prebiotics. TIM: The Netherlands Organization for Applied Scientific Research intestinal model, SHIME: simulator of the human intestinal microbial ecosystem, SCFAs: short-chain fatty acids, HPLC: High-performance liquid chromatography, GC: gas chromatography, HILIC: hydrophilic interaction liquid chromatography, LC–ESI–MS: liquid chromatography–electrospray ionization–mass spectrometry, RT-PCR: real-time polymerase chain reaction, qPCR: quantitative polymerase chain reaction, DGGE: denaturing gradient gel electrophoresis, T-RFLP: terminal restriction fragment length polymorphism, rRNA: ribosomal ribonucleic acid.
Figure 2
Figure 2
Mechanism of action of prebiotics. SCFAs—Short-chain fatty acids.
Figure 3
Figure 3
Chemical structure of main types of cyclodextrins.
Figure 4
Figure 4
Structure of dextran.
See this image and copyright information in PMC

References

    1. Hrncir T. Gut Microbiota Dysbiosis: Triggers, Consequences, Diagnostic and Therapeutic Options. Microorganisms. 2022;10:578. doi: 10.3390/microorganisms10030578. - DOI - PMC - PubMed
    1. Bedu-Ferrari C., Biscarrat P., Langella P., Cherbuy C. Prebiotics and the Human Gut Microbiota: From Breakdown Mechanisms to the Impact on Metabolic Health. Nutrients. 2022;14:2096. doi: 10.3390/nu14102096. - DOI - PMC - PubMed
    1. Davani-Davari D., Negahdaripour M., Karimzadeh I., Seifan M., Mohkam M., Masoumi S.J., Berenjian A., Ghasemi Y. Prebiotics: Definition, Types, Sources, Mechanisms, and Clinical Applications. Foods. 2019;8:92. doi: 10.3390/foods8030092. - DOI - PMC - PubMed
    1. Elder D.P., Kuentz M., Holm R. Pharmaceutical Excipients—Quality, Regulatory and Biopharmaceutical Considerations. Eur. J. Pharm. Sci. 2016;87:88–99. doi: 10.1016/j.ejps.2015.12.018. - DOI - PubMed
    1. Ionova Y., Wilson L. Biologic Excipients: Importance of Clinical Awareness of Inactive Ingredients. PLoS ONE. 2020;15:e0235076. doi: 10.1371/journal.pone.0235076. - DOI - PMC - PubMed

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