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. 2024 Nov 16;16(22):3914.
doi: 10.3390/nu16223914.

Movement Behaviors and Bone Biomarkers in Young Pediatric Cancer Survivors: A Cross-Sectional Analysis of the iBoneFIT Project

Jose J Gil-Cosano  1   2 , Esther Ubago-Guisado  2   3 , Francisco J Llorente-Cantarero  4   5   6 , Andres Marmol-Perez  2 , Andrea Rodriguez-Solana  2 , Juan F Pascual-Gazquez  7 , Maria E Mateos  4   8 , Jose R Molina-Hurtado  8 , Beatriz Garcia-Fontana  3   9   10 , Pedro Henrique Narciso  11 , Panagiota Klentrou  12   13 , Luis Gracia-Marco  2
Affiliations

Movement Behaviors and Bone Biomarkers in Young Pediatric Cancer Survivors: A Cross-Sectional Analysis of the iBoneFIT Project

Jose J Gil-Cosano et al. Nutrients. .

Abstract

Background/objectives: This study aims to investigate the association of movement behaviors with irisin, sclerostin, and bone turnover markers in young pediatric cancer survivors.

Methods: A total of 116 young pediatric cancer survivors (12.1 ± 3.3 years; 42% female) were recruited. Time spent in movement behaviors over at least seven consecutive 24 h periods was measured by accelerometers (wGT3x-BT accelerometer, ActiGraph). Blood samples were collected at rest and serum was analyzed for irisin, sclerostin, cross-linked telopeptide of type I collagen (CTX), procollagen type I amino-terminal propeptide (P1NP), total osteocalcin (OC), alkaline phosphatase (ALP), 25-hydroxyvitamin D, parathyroid hormone (PTH), calcium, phosphorous, and magnesium.

Results: Irisin and sclerostin were not significantly correlated with bone turnover markers. Sedentary time was negatively correlated with the P1NP (r = -0.411, p = 0.027) and total OC (r = -0.479, p = 0.015) Z-scores, whereas moderate-to-vigorous physical activity was positively correlated with the P1NP (r = 0.418, p = 0.024) and total OC (r = 0.478, p = 0.016) Z-scores. Moreover, total physical activity was positively correlated with the total OC Z-score (r = 0.448, p = 0.025). Finally, the uncoupling index [CTX/P1NP] was positively correlated with sedentary time (r = 0.424, p = 0.012) and negatively correlated with light physical activity (r = -0.352, 0.041).

Conclusions: Reducing sedentary time and increasing physical activity may favor bone formation over resorption in young pediatric cancer survivors.

Keywords: bone turnover; cancer; children; exercise; myokines; osteokines.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Flowchart of the study. PA, physical activity; PTH, parathyroid hormone; ALP, alkaline phosphatase; CTX, collagen type I cross-linked C-telopeptide; P1NP, procollagen type I N-terminal propeptide; OC, osteocalcin.
Figure 2
Figure 2
Bone marker plot with 95% confidence ellipsis from (A) CTX/P1NP and (B) CTX/OC.
Figure 3
Figure 3
Relationships of circulating sclerostin (panel (A–C)) and irisin (panel (D–F)) with bone turnover markers. CTX, collagen type I cross-linked C-telopeptide; P1NP, procollagen type I N-terminal propeptide; OC, osteocalcin.
Figure 4
Figure 4
Relationships between movement behaviors and the uncoupling index CTX/P1NP (panel (A–D)) and the uncoupling index CTX/OC (panel (E–H)). SB, sedentary behavior; LPA, light physical activity; MVPA, moderate-to-vigorous physical activity; CTX, collagen type I cross-linked C-telopeptide; P1NP, procollagen type I N-terminal propeptide; OC, osteocalcin. Boldface indicates statistical significance.
See this image and copyright information in PMC

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