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. 2024 Nov 18;16(22):3926.
doi: 10.3390/nu16223926.

Positive Changes in Body Composition and Profiles of Individuals with Diabetes 3 Years Following Laparoscopic Sleeve Gastrectomy in Japanese Patients with Obesity

Yoshinori Ozeki  1   2 , Takayuki Masaki  1   2   3 , Shotaro Miyamoto  1 , Yuichi Yoshida  1 , Mitsuhiro Okamoto  1 , Koro Gotoh  1   2   4 , Yuichi Endo  2   5 , Masafumi Inomata  5 , Hirotaka Shibata  1   2
Affiliations

Positive Changes in Body Composition and Profiles of Individuals with Diabetes 3 Years Following Laparoscopic Sleeve Gastrectomy in Japanese Patients with Obesity

Yoshinori Ozeki et al. Nutrients. .

Abstract

Background and objectives: We analyzed the changes in obesity, glucose metabolism, and body composition over a 3-year period in Japanese patients with obesity following laparoscopic sleeve gastrectomy (LSG).

Methods: Body weight, parameters related to diabetes such as glycated hemoglobin (HbA1c), and electrical impedance analysis were used to assess body composition in forty-eight Japanese patients with obesity before surgery and 6 months, 1 year, 2 years, and 3 years after LSG.

Results: At 6 months, 1, 2, and 3 years post-LSG, there were significant reductions in body weight, body mass index, blood pressure, fasting plasma glucose, triglyceride, and HbA1c levels. Six months after LSG, fat mass (FM), muscle mass (MM), and %FM all showed a decrease compared to pre-treatment values (all p < 0.05). FM and %FM remained in a decreased state until 3 years had passed. In contrast, %MM increased at 6 months post-LSG and was maintained up to 3 years post-LSG (all p < 0.05). Furthermore, changes in FM and %FM were associated with changes in body weight and A1C. In contrast, change in %MM exhibited a negative correlation with body weight and A1C following LSG. Finally, multivariate regression analyses demonstrated that alterations in FM were independent factors affecting body weight in patients with obesity 3 years after LSG.

Conclusions: We observed improvements in FM, fasting plasma glucose, and HbA1c levels over a 3-year period in Japanese patients after LSG. The reduction in FM and maintenance of %MM after LSG were suggested as possible links between the effects of LSG on obesity and diabetes over 3 years.

Keywords: body composition; diabetes; fat mass; laparoscopic sleeve gastrectomy; obesity.

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Conflict of interest statement

The authors state that the research was carried out without any financial relationships that might be seen as possible conflicts of interest.

Figures

Figure 1
Figure 1
Flow chart of this study participants.
Figure 2
Figure 2
The relationship between variations in glycemic metabolic parameters and body composition. (a) Association between BW and FM, (b) association between FPG and FM, and (c) association between HbA1c and % TMM. Variables: Δ (0–3 years) variables, BW: body weight, MM: muscle mass, FPG: fasting plasma glucose, HbA1c: hemoglobin A1c. Correlation coefficients were simply calculated. r = correlation coefficient.
Figure 2
Figure 2
The relationship between variations in glycemic metabolic parameters and body composition. (a) Association between BW and FM, (b) association between FPG and FM, and (c) association between HbA1c and % TMM. Variables: Δ (0–3 years) variables, BW: body weight, MM: muscle mass, FPG: fasting plasma glucose, HbA1c: hemoglobin A1c. Correlation coefficients were simply calculated. r = correlation coefficient.
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