Is it time to implement prolonged infusions of beta-lactam antibiotics in and beyond critical care settings?

Mohd H Abdul-Aziz¹, Joel M Dulhunty^{2

3

4

5}, Dorrilyn Rajbhandari⁵, Jason A Roberts^{1

2

6

7}, Jeffrey Lipman^{1

2

5

7

8}

Affiliations

¹ University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.
² Intensive Care Services, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.
³ Medical Administration, Redcliffe Hospital, Redcliffe, Queensland, Australia.
⁴ Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.
⁵ Critical Care Program, The George Institute for Global Health and University of New South Wales, Sydney, New South Wales, Australia.
⁶ Herston Infectious Diseases Institute, Metro North Health, Brisbane, Queensland, Australia.
⁷ Division of Anaesthesiology Critical Care Emergency and Pain Medicine, Nîmes University Hospital, University of Montpellier, Nîmes, France.
⁸ Jamieson Trauma Institute, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.

Editorial

Mohd H Abdul-Aziz et al. Intern Med J. 2024 Dec.

. 2024 Dec;54(12):1931-1934.

doi: 10.1111/imj.16584. Epub 2024 Nov 26.

Mohd H Abdul-Aziz¹, Joel M Dulhunty^{2

3

4

5}, Dorrilyn Rajbhandari⁵, Jason A Roberts^{1

2

6

7}, Jeffrey Lipman^{1

2

5

7

8}

¹ University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.
² Intensive Care Services, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.
³ Medical Administration, Redcliffe Hospital, Redcliffe, Queensland, Australia.
⁴ Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.
⁵ Critical Care Program, The George Institute for Global Health and University of New South Wales, Sydney, New South Wales, Australia.
⁶ Herston Infectious Diseases Institute, Metro North Health, Brisbane, Queensland, Australia.
⁷ Division of Anaesthesiology Critical Care Emergency and Pain Medicine, Nîmes University Hospital, University of Montpellier, Nîmes, France.
⁸ Jamieson Trauma Institute, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.

No abstract available

References

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1. Bauer M, Gerlach H, Vogelmann T, Preissing F, Stiefel J, Adam D. Mortality in sepsis and septic shock in Europe, North America and Australia between 2009 and 2019 – results from a systematic review and meta‐analysis. Crit Care 2020; 24: 239.
1. Li L, Sunderland N, Rathnayake K, Westbrook JI. Epidemiology of Sepsis in Australian Public Hospitals. Sydney, New South Wales: Australian Commission on Safety and Quality in Health Care; 2020.
1. The George Institute for Global Health. Cost of Sepsis in Australia. Sydney New South Wales: The George Institute for Global Health; 2021.
1. Craig WA. Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men. Clin Infect Dis 1998; 26: 1–10.