Kidney function estimated by creatinine and cystatin C and adverse cardiovascular outcomes in patients with atrial fibrillation

Adrian Schweigler^{1

2}, Elisa Hennings^{1

2}, Stefanie Aeschbacher^{1

2}, Désirée Carmine^{1

2}, Tobias Reichlin³, Nicolas Rodondi^{4

5}, Annina Stauber⁶, Peter Ammann⁷, Giorgio Moschovitis⁸, Lucy Bolt^{4

5}, Andrea Demarchi⁹, Andreas S Mueller⁶, Danielle Reneau², Michael Coslovsky^{2

10}, Christine S Zuern^{1

2}, Leo H Bonati¹¹, David Conen¹², Stefan Osswald^{1

2}, Michael Kühne^{1

2}, Philipp Krisai^{1

2}; Swiss‐AF Investigators

Affiliations

¹ Cardiology/ Electrophysiology Division, Department of Medicine, University Hospital Basel, Basel, Switzerland.
² Cardiovascular Research Institute Basel, University Hospital Basel, University of Basel, Basel, Switzerland.
³ Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
⁴ Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.
⁵ Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
⁶ Department of Cardiology, Triemli Hospital Zurich, Zurich, Switzerland.
⁷ Department of Cardiology, Kantonsspital St Gallen, St Gallen, Switzerland.
⁸ Division of Cardiology, Ospedale Regionale di Lugano, Ente Ospedaliero Cantonale, Lugano, Switzerland.
⁹ Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale, Lugano, Switzerland.
¹⁰ Clinical Trial Unit Basel, Department of Clinical Research, University Hospital Basel, Basel, Switzerland.
¹¹ Department of Neurology and Stroke Center, University Hospital Basel, University of Basel, Basel, Switzerland.
¹² Health Research Institute, McMaster University, Hamilton, Ontario, Canada.

Adrian Schweigler et al. J Intern Med. 2025 Mar.

. 2025 Mar;297(3):335-338.

doi: 10.1111/joim.20036. Epub 2024 Nov 27.

¹ Cardiology/ Electrophysiology Division, Department of Medicine, University Hospital Basel, Basel, Switzerland.
² Cardiovascular Research Institute Basel, University Hospital Basel, University of Basel, Basel, Switzerland.
³ Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
⁴ Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.
⁵ Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
⁶ Department of Cardiology, Triemli Hospital Zurich, Zurich, Switzerland.
⁷ Department of Cardiology, Kantonsspital St Gallen, St Gallen, Switzerland.
⁸ Division of Cardiology, Ospedale Regionale di Lugano, Ente Ospedaliero Cantonale, Lugano, Switzerland.
⁹ Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale, Lugano, Switzerland.
¹⁰ Clinical Trial Unit Basel, Department of Clinical Research, University Hospital Basel, Basel, Switzerland.
¹¹ Department of Neurology and Stroke Center, University Hospital Basel, University of Basel, Basel, Switzerland.
¹² Health Research Institute, McMaster University, Hamilton, Ontario, Canada.

No abstract available

Keywords: atrial fibrillation; biomarker; cardiovascular risk; chronic kidney disease; cystatin C..

References

1. Malmgren L, Öberg C, den Bakker E, Leion F, Siódmiak J, Åkesson A, et al. The complexity of kidney disease and diagnosing it—cystatin C, selective glomerular hypofiltration syndromes and proteome regulation. J Intern Med. 2023;293:293–308.
1. Grubb A, Lindström V, Jonsson M, Bäck SE, Åhlund T, Rippe B, et al. Reduction in glomerular pore size is not restricted to pregnant women. Evidence for a new syndrome: “Shrunken pore syndrome”. Scand J Clin Lab Invest. 2015;75:333–340.
1. Conen D, Rodondi N, Mueller A, Beer JH, Auricchio A, Ammann P, et al. Design of the Swiss Atrial Fibrillation Cohort Study (Swiss‐AF): structural brain damage and cognitive decline among patients with atrial fibrillation. Swiss Med Wkly. 2017;147:w14467.
1. Ruperti Repilado FJ, Doerig L, Blum S, Aeschbacher S, Krisai P, Ammann P, et al. Prevalence and predictors of atrial fibrillation type among individuals with recent onset of atrial fibrillation. Swiss Med Wkly. 2018;148:w14652.
1. Inker LA, Schmid CH, Tighiouart H, Eckfeldt JH, Feldman HI, Greene T, et al. Estimating glomerular filtration rate from serum creatinine and cystatin C. N Engl J Med. 2012;367:20–29.