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. 2024 Dec;71(6):740-742.
doi: 10.1165/rcmb.2024-0193LE.

Regenerative Signatures in BAL of Acute Respiratory Distress Syndrome

Runzhen Zhao  1 , Marco Hadisurya  2 , Harrison Ndetan  3 , Nan Miles Xi  4 , Sitaramaraju Adduri  3 , Nagarjun Venkata Konduru  3 , Buka Samten  3 , Jiwang Zhang  5 , W Andy Tao  2 , Karan P Singh  3 , Hong-Long Ji  1
Affiliations

Regenerative Signatures in BAL of Acute Respiratory Distress Syndrome

Runzhen Zhao et al. Am J Respir Cell Mol Biol. 2024 Dec.
No abstract available

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Figures

Figure 1.
Figure 1.
Extracellular vesicle protein signatures of BAL fluid in patients with acute respiratory distress syndrome (ARDS). (A) Volcano plots of proteins in patients with mild and severe ARDS. (B) Venn plot showing the overlap of upregulated exosomal proteins (n = 12 participants). (C) Cellular origin of differentiated exosomal proteins. (D) Top 14 biological processes per ARDS stage for downregulated differentially expressed proteins. (E) Adjusted effect size of severity (the ratio of arterial oxygen tension/pressure to the fraction of inspired oxygen)–associated proteins with 95% confidence intervals adjusted for age, sex, and race. Negative adjusted effect size values indicate negative associations between the protein and ARDS severity. The red line represents the overall weighted effect size positively correlating with severity. (F) Heat maps of the pathways for realveolarization. Hits of the same signaling pathway identified by EnrichR were pooled. (G) Integration of ARDS stage–specific downregulated differentially expressed proteins, Gene Ontology terms, functional annotations, and diseases in AT2 cells. The AT2 cell–prioritized ontology of differentiated exosomal proteins, including genes, diseases, signals, molecular functions, and biological processes, was analyzed using ToppGene. FDR = false discovery rate; SCF = stem cell factor.
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