Spontaneous regression of paediatric pituitary lesions-report of 2 cases and literature review

Abstract

Objective: Pituitary lesions are rare in the pediatric population. They consist of a heterogenous group of neoplasms including pituitary adenomas (PA) and Rathke cleft cysts (RCC). Their natural history, management strategies, and long-term outcomes are mostly extrapolated from adult experience. Neurosurgical intervention may be necessary for large and/or symptomatic lesions. Of note, the likelihood of their spontaneous regression is uncommon. We report 2 interesting cases of such a phenomenon for these lesions and discuss our findings in corroboration with current literature.

Methods and results: Two cases of spontaneous regression of pituitary lesions observed on serial neuroimaging are described. Based on their clinical history and radiological characteristics, the working diagnoses were that of a non-functioning PA and RCC, respectively. A systematic search of relevant publications in the English language is performed in PubMed and Google Scholar. Our findings show that there are 14 reported cases (including 1 of our patients) of spontaneous regression of non-functioning PA with good outcomes. Pertaining to RCCs, the limited evidence suggests that the incidence of their spontaneous regression is approximately 30%, similar to what is reported in the adult population. A separate discussion on the possible differential diagnosis of lymphocytic hypophysitis is also highlighted.

Conclusion: Pediatric pituitary lesions may present with unpredictable natural histories, as highlighted in our case examples. We advocate an extended period of follow-up by a cohesive multidisciplinary team. In meantime, collaborative efforts should focus on the establishing clinical practice guidelines to optimize the management of pituitary lesions in children.

Keywords: Pituitary adenoma; Pituitary lesion; Rathke’s cleft cyst.