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Published Erratum
. 2024 Dec 3;121(49):e2423018121.
doi: 10.1073/pnas.2423018121. Epub 2024 Nov 27.

Correction for Johnson et al., L-type Ca2+ channel blockers promote vascular remodeling through activation of STIM proteins

No authors listed
Published Erratum

Correction for Johnson et al., L-type Ca2+ channel blockers promote vascular remodeling through activation of STIM proteins

No authors listed. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Fig. 7.
Fig. 7.
LCCBs promote vascular remodeling through STIM1. (A) STIM1 western blots of VSMCs transfected with Scrambled shRNA (shScr.) and two STIM1shRNA (shSTIM1#1 [shS1 #1] and shSTIM1#2 [shS1 #2]). (B) STIM1 protein quantification from A using densitometry normalized to tubulin. (C) SOCE triggered by thapsigargin in VSMC stably expressing either shScramble, or shSTIM1#1, or shSTIM1#2. (D) Quantification of maximal Ca2+ entry from C. (E) Quantification of VSMC migration at 24 h in ShScramble and shSTIM1-expressing VSMCs treated with either 0.5 ng/mL PDGF or 0.5 μM amlodipine +0.5 ng/mL PDGF. (F) Quantification in normalized relative fluorescence units (RFU) of proliferation in ShScramble- and shSTIM1-expressing VSMCs treated with either 0.5 ng/mL PDGF or 0.5 μM amlodipine + 0.5 ng/mL PDGF. (G) Bright field images of VSMC migration from E. (Scale bar: 500 μm.) (H) STIM1 and STIM2 western blots in VSMCs acutely isolated from endothelial-denuded aortic rings of SHR and WKY rats. (I and J) Quantification of STIM1 (I) and STIM2 (J) in WKY and SHR normalized to tubulin. (K) SOCE measurements from SHR and WKY VSMCs. (L) Quantification of maximal Ca 2+ entry from K. (M and N) Whole-cell ICRAC induced by 1,2-bis(o-aminophenoxy)ethane-N,N,N′,N′-tetra acetic acid (BAPTA) in VSMCs from WKY (M) and SHR (N). Divalent free (DVF) bath solution was used to potentiate a Na + current. (O) Ca2+ ICRAC and (P) Na+ ICRAC I/V relationships obtained from M and N where indicated by numbers (1 to 4). (Q) Peak Ca2+ ICRAC and (R) peak Na+ ICRAC densities from SHR and WKY VSMCs. (S) Data from Penn State University Hospital with reported cases of heart failure when patients are treated with LCCBs or other antihypertensive drugs. Exposed control did not develop heart failure to date. The last row reports pooled patients exposed to antihypertensive drugs that are not LCCBs. (T) Odds ratio of tabulated results in S. Error bars are 95% CIs (*P < 0.05, ***P < 0.001; unpaired Student’s t test). ANOVA and Dunnett’s multiple comparison test were used for B and D, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. (E and G) #P < 0.05, ##P < 0.01, ###P < 0.001 when compared to 0.5 ng/mL PDGF.
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