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. 2024 Dec;45(12):922-924.
doi: 10.1016/j.it.2024.11.004. Epub 2024 Nov 27.

How do autoimmune CD4+ T cells handle exhaustion?

Astrid Fabri  1 , Lucy S K Walker  2
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Free article

How do autoimmune CD4+ T cells handle exhaustion?

Astrid Fabri et al. Trends Immunol. 2024 Dec.
Free article

Abstract

Chronic antigen exposure is frequently associated with T cell exhaustion. In a recent study, Aljobaily et al. show that pancreatic islet-infiltrating CD4+ T cells in mouse autoimmune diabetes may circumvent exhaustion by preserving TCF1 expression. Continuous recruitment of epigenetically pre-programmed CD62L+ CD4+ T cells seems to sustain the local autoimmune response.

Keywords: CD4 T cell; autoimmunity; exhaustion; stemness; type 1 diabetes.

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Conflict of interest statement

Declaration of interests The authors declare no conflicts of interest.

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