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Review
. 2025 Feb;24(2):e16688.
doi: 10.1111/jocd.16688. Epub 2024 Nov 27.

Influences on Skin and Intrinsic Aging: Biological, Environmental, and Therapeutic Insights

Ramadan S Hussein  1 , Salman Bin Dayel  1 , Othman Abahussein  1 , Abeer Ali El-Sherbiny  2
Affiliations
Review

Influences on Skin and Intrinsic Aging: Biological, Environmental, and Therapeutic Insights

Ramadan S Hussein et al. J Cosmet Dermatol. 2025 Feb.

Abstract

Background/aim: Aging involves a progressive deterioration in physiological functions and increased disease susceptibility, impacting all organs and tissues, especially the skin. Skin aging is driven by intrinsic factors (genetics, cellular metabolism) and extrinsic factors (environment, lifestyle). Understanding these mechanisms is vital for promoting healthy aging and mitigating skin aging effects. This review aims to summarize the key factors influencing skin and intrinsic aging, providing a comprehensive understanding of the underlying mechanisms and contributing elements.

Methods: A comprehensive literature review was conducted, focusing on peer-reviewed journals, clinical studies, and scientific reviews published within the last two decades. The inclusion criteria prioritized studies that addressed intrinsic and extrinsic mechanisms of skin aging. To ensure the relevance and quality of the selected sources, a systematic approach was used to assess study design, sample size, methodology, and the significance of the findings in the context of skin aging.

Findings: The review identifies major internal factors, such as cellular senescence, genetic predisposition, telomere shortening, oxidative stress, hormonal changes, metabolic processes, and immune system decline, as pivotal contributors to intrinsic aging. External factors, including UV radiation, pollution, lifestyle choices (diet, smoking, alcohol consumption, and sleep patterns), and skincare practices, significantly influence extrinsic skin aging. The interplay between these factors accelerates aging processes, leading to various clinical manifestations like wrinkles, loss of skin elasticity, pigmentation changes, and texture alterations.

Conclusion: A comprehensive understanding of both extrinsic and intrinsic factors contributing to skin aging is essential for developing effective prevention and intervention strategies. The insights gained from this review highlight the importance of a multifaceted approach, incorporating lifestyle modifications, advanced skincare routines, and emerging therapeutic technologies, to mitigate the effects of aging and promote healthier, more resilient skin.

Keywords: biological mechanisms; environmental factors; extrinsic aging; intrinsic aging; skin aging.

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Conflict of interest statement

The authors declare no conflicts of interest.

References

    1. Hayflick L., “The Future of Ageing,” Nature 408, no. 6809 (2000): 267–269. - PubMed
    1. Kirkwood T. B. L., “Understanding the Odd Science of Aging,” Cell 120, no. 4 (2005): 437–447. - PubMed
    1. Gilchrest B. A., “Photoaging,” Journal of Investigative Dermatology 133, no. E1 (2013): E2–E6. - PubMed
    1. Schneider M. R. and Mitsui H., “The Relationship Between Skin and Systemic Aging,” Dermatology Clinics 36, no. 1 (2018): 81–90.
    1. Yaar M. and Gilchrest B. A., “Photoageing: Mechanism, Prevention and Therapy,” British Journal of Dermatology 157, no. 5 (2007): 874–887. - PubMed