Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Nov 28;23(1):393.
doi: 10.1186/s12944-024-02378-5.

The association between neutrophil and lymphocyte to high-density lipoprotein cholesterol ratio and metabolic syndrome among Iranian population, finding from Bandare Kong cohort study

Seyyed Mohammad Hashemi  1   2 , Masoumeh Kheirandish  3 , Shideh Rafati  4 , Arezoo Ghazalgoo  1   2 , Ehsan Amini-Salehi  5 , Mohammad-Hossein Keivanlou  5   6 , Shahin Abbaszadeh  2 , Parsa Saberian  7   8 , Arash Rahimi  9
Affiliations

The association between neutrophil and lymphocyte to high-density lipoprotein cholesterol ratio and metabolic syndrome among Iranian population, finding from Bandare Kong cohort study

Seyyed Mohammad Hashemi et al. Lipids Health Dis. .

Abstract

Background: Metabolic Syndrome (MetS) is characterized by the co-occurrence of various metabolic risk factors, significantly increasing the risk of cardiovascular diseases (CVD) and type 2 diabetes (T2DM). This study investigates the potential of hematological indices, specifically the neutrophil to high-density lipoprotein cholesterol ratio (NHR) and lymphocyte to high-density lipoprotein cholesterol ratio (LHR), as predictors of MetS in a population from southern Iran.

Methods: Utilizing baseline data from the Bandare-Kong Non-Communicable Diseases (BKNCD) Cohort, part of the Prospective Epidemiological Research Studies in IrAN (PERSIAN), A total of 2,684 participants aged 35-70 years were analyzed. Participants were evaluated using the Iranian National Cholesterol Education Program (NCEP) criteria to diagnose MetS. Receiver operating characteristic (ROC) analysis was conducted to assess the predictive validity of NHR and LHR across different demographic categories.

Results: The mean LHR and NHR values were significantly higher in individuals diagnosed with MetS (P < 0.001). Specifically, the LHR was 0.85 ± 0.26 in MetS patients compared to 0.76 ± 0.23 in those without MetS, while the NHR was 1.33 ± 0.35 in MetS patients compared to 1.20 ± 0.32 in those without MetS. After adjusting for confounding factors, both LHR and NHR remained significantly associated with MetS, with odds ratios (OR) of 6.61 (95% CI: 4.43-9.83) for LHR and 4.76 (95% CI: 3.51-6.45) for NHR. Among MetS components, LHR was associated with low HDL cholesterol and elevated triglycerides, while NHR showed significant associations with central obesity, low HDL cholesterol, and elevated triglycerides. ROC analysis revealed moderate predictive capabilities for both indices, with areas under the curve of 0.60 for LHR and 0.61 for NHR.

Conclusion: The findings suggest that NHR and LHR are promising, easily obtainable hematological markers for predicting MetS. These indices could serve as valuable tools for early detection and ongoing monitoring in clinical settings, aiding in the prevention and management of MetS.

Keywords: Lymphocyte to high-density lipoprotein cholesterol ratio; Metabolic syndrome; Neutrophil to high-density lipoprotein cholesterol ratio; Prospective epidemiological research studies in IrAN (PERSIAN).

PubMed Disclaimer

Conflict of interest statement

Declarations. Ethics approval and consent to participate: The study obtained informed consent from all subjects. For the vulnerable population, informed consent was obtained from parents or legal guardians. The study protocol underwent thorough evaluation and received approval from the Ethics Committee of Hormozgan University of Medical Sciences (Ethics Code: IRC.HUMS.REC.1401.320), aligning with the ethical principles outlined in the Declaration of Helsinki. Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
ROC curve displaying the ability of NHR and LHR to predict MetS according to sex
See this image and copyright information in PMC

References

    1. Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, Fruchart J-C, James WPT, Loria CM, Smith SC Jr. Harmonizing the metabolic syndrome: a joint interim statement of the international diabetes federation task force on epidemiology and prevention; national heart, lung, and blood institute; American heart association; world heart federation; international atherosclerosis society; and international association for the study of obesity. Circulation. 2009;120:1640–5. - DOI - PubMed
    1. Amini-Salehi E, Letafatkar N, Norouzi N, Joukar F, Habibi A, Javid M, Sattari N, Khorasani M, Farahmand A, Tavakoli S, et al. Global prevalence of nonalcoholic fatty liver disease: an updated review Meta-analysis comprising a Population of 78 million from 38 countries. Arch Med Res. 2024;55:103043. - DOI - PubMed
    1. Mahapatro A, Bozorgi A, Obulareddy SUJ, Jain SM, Reddy Korsapati R, Kumar A, Patel K, Soltani Moghadam S, Arya A, Jameel Alotaibi A, et al. Glucagon-like peptide-1 agonists in cardiovascular diseases: a bibliometric analysis from inception to 2023. Ann Med Surg (Lond). 2024;86:6602–18. - DOI - PMC - PubMed
    1. Mente A, Yusuf S, Islam S, McQueen MJ, Tanomsup S, Onen CL, Rangarajan S, Gerstein HC, Anand SS, Investigators I. Metabolic syndrome and risk of acute myocardial infarction: a case-control study of 26,903 subjects from 52 countries. J Am Coll Cardiol. 2010;55:2390–8. - DOI - PubMed
    1. O’Neill S, O’Driscoll L. Metabolic syndrome: a closer look at the growing epidemic and its associated pathologies. Obes Rev. 2015;16:1–12. - DOI - PubMed

LinkOut - more resources