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Comparative Study
. 2024 Nov 27;24(1):586.
doi: 10.1186/s12890-024-03408-9.

Comparison of impulse oscillometry measurements according to body mass index in patients with asthma

Sami Deniz  1   2 , Nil Kuranoğlu  3
Affiliations
Comparative Study

Comparison of impulse oscillometry measurements according to body mass index in patients with asthma

Sami Deniz et al. BMC Pulm Med. .

Abstract

Background: Obesity can lead to increased airway resistance, especially in the peripheral airways. Impulse oscillometry (IOS) may detect small airway changes in asthma. In this study, we aimed to investigate the effect of obesity on the small airways of the lungs in asthmatic patients by IOS measurements.

Methods: One hundred newly diagnosed asthmatic patients (28 male) were divided into three groups (BMI (< 25.0 kg/m2: Group-1; 25.0 to 29.9 kg/m2: Group-2; ≥30 kg/m2: Group-3). Demographic data, comorbidities, Beck anxiety and depression questionnaires, PFTs, and IOS measurements of the patients were recorded.

Results: There was no detected significant difference concerning age, gender, smoking history, pack year, comorbidities (except hypertension and anxiety), asthma cardinal symptoms (except dyspnea), and pulmonary function tests among groups (p > 0.05). There were significant differences regarding R5, R5%, R20%, X5, X20, Fres, and R5-R20 among the three groups. Group 1 significantly differed about R5-R20, X5, AX, and Fres compared to groups 2 and 3 in pairwise comparisons. Based on these results, a difference was detected between BMI < 25 and ≥ 25. There was only one significant variable (R20%) between BMI < 30 and ≥ 30. When performing a correlation test between IOS parameters and BMI, it was observed to be significantly correlated (p < 0.05) except X5% and X20% (p > 0.05).

Conclusion: Obesity and being overweight affected peripheral airways and reactance; however, obesity also affects central airways, based on our results. In addition, it was thought that IOS may detect earlier than PFTs on small airway changes.

Keywords: Asthma; Impulse oscillometry; Obesity; Small airways.

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: The study was approved by the Institutional Review Board for Human Studies and Ethics Committee (2023/65–70) University of Health Sciences Turkey Medical Faculty, Dr Suat Seren Chest Diseases and Thoracic Surgery Research and Education Hospital, Ethics Committee) and was conducted using the principles of the Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
The correlation test between IOS parameters and BMI
See this image and copyright information in PMC

References

    1. Global Initiative for Asthma (GINA). Global strategy for asthma management and prevention. http://www.ginasthma.org. Accessed 2023.
    1. Siora A, Vontetsianos A, Chynkiamis N, et al. Small airways in asthma: from inflammation and pathophysiology to treatment response. Respir Med. 2024;222:107532. - PubMed
    1. Kelly MM et al. Pathology of Asthma. In: Burks AW, O’Hehir RE, Broide DH, editors. Middleton Allergy Principles and Practice 9th Edition Chapter:57, Amsterdam, 2019, Academic, p: 957–969.
    1. Thamrin C, Dellacà RL, Hall GL, et al. Technical standards for respiratory oscillometry: test loads for calibration and verification. Eur Respir J. 2020;56(4):2003369. - PubMed
    1. Li LY, Yan TS, Yang J, et al. Impulse oscillometry detects small airway dysfunction in subjects with chronic respiratory symptoms and preserves pulmonary function. Respir Res. 2021;22(1):68. - PMC - PubMed

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