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[Preprint]. 2024 Nov 15:arXiv:2411.10421v1.

Deciphering SCN2A: A comprehensive review of rodent models of Scn2a dysfunction

Katelin E J Scott  1   2   3 , Maria F Hermosillo Arrieta  4   2   3 , Aislinn J Williams  2   3
Affiliations

Deciphering SCN2A: A comprehensive review of rodent models of Scn2a dysfunction

Katelin E J Scott et al. ArXiv. .

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Figures

Figure 1:
Figure 1:
Summerized main behavioral findings from the SCN2A +/− mouse model. See a more detailed summary of behavioral experiments in Supplemental table 2. Created in BioRender. Williams lab, A. (2024) https://BioRender.com/b81m903
Figure 2:
Figure 2:
Summary of main behavioral findings from other constitutive haploinsufficient Scn2a mouse models. Model constructs not included in this summary table either did not evaluate behavior or did not identify results in their Scn2a model construct distinct from wildtype animals. See a more detailed summary of behavioral assessment in these animals in Supplementary table 2. (PTZ= pentylenetetrazole) Created in BioRender. Williams lab, A. (2024) https://BioRender.com/t38r001
Figure 3:
Figure 3:
Summary of main behavioral findings from Scn2a hypomorphic models. For a more detailed summary please See Supplementary table 2. Created in BioRender. Williams lab, A. (2024) https://BioRender.com/x74k536
Figure 4:
Figure 4:
Summary of main behavioral findings from conditional and tissue specific deletion of Scn2a in mice models. Model constructs not Included in this summary table either did not evaluate behavior or did not identify results in their SCN2A model construct distinct from wildtype animals. See a more detailed summary of behavioral assesment in these animals in Supplementray table 2. (VOR= Vestibular ocular reflex, SWD = Spike wake discharge) Created in BioRender. Williams lab, A. (2024) https://BioRender.com/c64k310
Figure 5:
Figure 5:
Summary of findings utilizing the Scn2aQ54 mouse construct on the mixed C57BL/6J x SJI/J background Created in BioRender. Williams lab, A. (2024) https://BloRender.com/h22y889
See this image and copyright information in PMC

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