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. 1986 Feb 21;8(1):29-34.
doi: 10.1007/BF01975476.

Pharmacokinetics: metabolism and renal excretion of quinolones in man

T B Vree, W J Wijnands, P J Guelen, A M Baars, Y A Hekster

Pharmacokinetics: metabolism and renal excretion of quinolones in man

T B Vree et al. Pharm Weekbl Sci. .

Abstract

The quinolones are relatively poorly absorbed from the gastrointestinal tract. The elimination proceeds mainly by renal excretion. The half-life of elimination depends on the molecular structure and varies between 2 and 10 h. Impaired kidney function is expected to increase the half-life of elimination, though this effect is not always observed. Since the 4-oxo-metabolites show a higher renal clearance than the parent drug, renal impairment will result in a cumulation of the metabolites in the body.

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