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. 2024 Dec;20(40):3471-3476.
doi: 10.1080/14796694.2024.2430164. Epub 2024 Nov 28.

Effect of dual bronchodilators plus preoperative rehabilitation in operable LC & chronic obstructive pulmonary disease

Rong Zhou  1 , Yan Qin  2 , Song Hu  1 , Yangyang Xu  1 , Chunlai Feng  1
Affiliations

Effect of dual bronchodilators plus preoperative rehabilitation in operable LC & chronic obstructive pulmonary disease

Rong Zhou et al. Future Oncol. 2024 Dec.

Abstract

Background: This study analyzed the application of dual bronchodilators in patients with non-small cell lung cancer (NSCLC) & chronic obstructive pulmonary disease (COPD) during the perioperative period.

Research design and methods: A total of 100 patients with moderate to severe COPD who underwent thoracoscopic lobectomy were divided into two groups. The patients in the observation group (group O) were treated with umeclidinium/vilanterol and conventional treatment (oxygen therapy, assisted expectoration, respiratory rehabilitation training) during the perioperative period. The patients in the control group (group C) received conventional treatment. Lung function, arterial blood gas values, quality of life, postoperative adverse reactions, days of postoperative chest tube placement and hospitalization were assessed.

Results: Before surgery, group O presented higher FEV1, FVC, PEF and MVV, elevated PO2 and reduced PCO2, lower CAT scores compared with the group C (p < 0.05). The group O demonstrated fewer perioperative adverse reactions, and shorter days of postoperative chest tube and hospitalization compared with the group C (p < 0.05).

Conclusions: Perioperative inhalation of umeclidinium/vilanterol can effectively protect arterial blood gas and respiratory function in patients with LC complicated with COPD.

Keywords: Non-small cell lung cancer; arterial blood gas values; chronic obstructive pulmonary disease; dual bronchodilators; lung function; perioperative period; quality of life.

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Conflict of interest statement

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Figures

Figure 1.
Figure 1.
Comparison of lung function indices of patients in group O and Group C.
See this image and copyright information in PMC

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