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Review
. 2024 Nov 28;383(1):1.
doi: 10.1007/s41061-024-00483-8.

Organelle-Specific Smart Supramolecular Materials for Bioimaging and Theranostics Application

Dineshkumar Bharathidasan  1 , Chandan Maity  2
Affiliations
Review

Organelle-Specific Smart Supramolecular Materials for Bioimaging and Theranostics Application

Dineshkumar Bharathidasan et al. Top Curr Chem (Cham). .

Abstract

In cellular environments, certain synthetic molecules can form nanostructures via self-assembly, impacting molecular imaging, and biomedical applications. Control over the formation of these self-assembled nanostructures in subcellular organelle is challenging. By the action of stimuli, either present in the cellular environment or applied externally, in situ generation of molecular precursors can lead to accumulation and supramolecular nanostructure formation, resulting in efficient bioimaging. Here, we summarize smart fluorophore-based ordered nanostructure preparation at specific organelles for efficient bioimaging and therapeutic application towards cancer theranostics. We also present challenges and an outlook regarding intercellular self-assembly for theranostics application. Altogether, smart nanostructured materials with fluorescence read-outs at specific subcellular compartments would be beneficial in synthetic biology and precision therapeutics.

Keywords: Bioimaging; Fluorescence; Hydrogel; Organelle; Stimuli-responsive; Supramolecular assembly.

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Conflict of interest statement

Declarations. Conflicts of Interest: There are no conflicts to declare. Ethics Approval and Consent to Participate: There are no human and animal subjects in this review and informed consent is not applicable.

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