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Meta-Analysis
. 2025 Jan;35(1):312-321.
doi: 10.1007/s11695-024-07599-2. Epub 2024 Nov 28.

Use of Probiotics and Synbiotics in the Treatment of Small Intestinal Bacterial Overgrowth (SIBO) and Other Gastrointestinal Symptoms After Metabolic Bariatric Surgery: a Systematic Review and Meta-Analysis

Nathalia Ramori Farinha Wagner  1 , Ricardo Fernandes  2 , Michelle Teixeira Frota Reichmann  3 , Maria Clara Peixoto Lopes  3 , Larissa Locatelli Swain Welc  4 , Antonio Carlos Ligocki Campos  3
Affiliations
Meta-Analysis

Use of Probiotics and Synbiotics in the Treatment of Small Intestinal Bacterial Overgrowth (SIBO) and Other Gastrointestinal Symptoms After Metabolic Bariatric Surgery: a Systematic Review and Meta-Analysis

Nathalia Ramori Farinha Wagner et al. Obes Surg. 2025 Jan.

Abstract

Metabolic bariatric surgery is considered the most effective treatment for severe obesity, however it may be associated with the development of Small Intestinal Bacterial Overgrowth (SIBO) and other gastrointestinal symptoms (GIS). This study conducted a systematic review and meta-analysis to evaluate the effects of probiotics or synbiotics on GIS and SIBO in post- metabolic bariatric surgery patients. Five studies that investigated the effect of probiotics or synbiotics in the treatment of post-surgery GIS were included in the review, with three focusing on SIBO. For the meta-analysis, three studies assessed GIS, and two examined SIBO. The results showed that probiotics did not offer significant benefits in treating GIS or SIBO in these patients.

Keywords: Bariatric surgery; Gastrointestinal symptoms; Meta-analysis; Probiotics.

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Conflict of interest statement

Declarations. Ethical Approval: For this type of study formal consent is not required. Informed Consent: Informed Consent does not apply. Competing Interests: The authors declare no competing interests.

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