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. 2024 Nov 28;64(1):30.
doi: 10.1007/s00394-024-03547-z.

A ferritin-related dietary pattern is positively associated with iron status but negatively associated with vitamin D status in pregnant women: a cross-sectional study

Arpita Das  1 , Chyi-Huey Bai  2   3   4 , Jung-Su Chang  1   4   5   6 , Ya-Li Huang  2   3 , Fan-Fen Wang  7 , Chien-Yeh Hsu  8   9 , Yi-Chun Chen  10 , Jane C-J Chao  11   12   13   14
Affiliations

A ferritin-related dietary pattern is positively associated with iron status but negatively associated with vitamin D status in pregnant women: a cross-sectional study

Arpita Das et al. Eur J Nutr. .

Abstract

Purpose: Vitamin D supplementation positively impacts anemia, but the relationship between a ferritin-related dietary pattern, iron parameters, and vitamin D in anemia is unclear.

Methods: This cross-sectional study analyzed data from the 2017-2019 National Nutrition and Health Survey, including 1423 pregnant women over 15 years old. Dietary intake was assessed using a semi-quantitative food frequency questionnaire and a 24-hour dietary recall. The FrDP was identified using reduced rank regression with blood parameters as response variables and 32 food groups as predictors. Linear and binomial logistic regression analyses evaluated the associations between the FrDP and serum biomarkers, adjusting for demographic and dietary variables. Risk associations between the FrDP and vitamin D concentrations were also assessed.

Results: The FrDP explained 18.5% of the variation in 6 response variables and was characterized by high consumption of fish, soy, gluten pasta, nuts, organ meat, pickled vegetables, and marine plants. The FrDP correlated positively with serum hemoglobin (r = 0.76), iron (r = 0.52), ferritin (r = 0.79), folate (r = 0.86), and vitamin B12 (r = 0.86). Linear regression revealed a positive association between the FrDP and serum iron. Women in the highest FrDP tertile were less likely to have low serum iron (OR = 0.65, 95% CI 0.50-0.85) but more likely to have low 25(OH) vitamin D concentrations (OR = 1.79, 95% CI 1.32-2.43).

Conclusions: The FrDP was positively associated with serum iron but negatively associated with serum 25(OH) vitamin D in pregnant women.

Keywords: Dietary pattern; Ferritin; Iron; Pregnant women; Vitamin D.

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Conflict of interest statement

Declarations. Ethical approval: The study was approved by the Joint Institutional Review Board of Taipei Medical University, Taiwan (approval no.: N201707039, approval date: November 7, 2018), and was conducted in accordance with ethical principles of the Declaration of Helsinki. Consent to participate: All participants signed the informed consent before enrolling the study. Conflict of interest: No author has any potential conflicts of interest.

Figures

Fig. 1
Fig. 1
Study population selection based on exclusion criteria. a, b,c In the final analysis, a total population of 1423 was retained for evaluating the association between the dietary pattern and pregnancy-associated anemia
Fig. 2
Fig. 2
Factor loadings of the ferritin-related dietary pattern (FrDP) > 0.20. a aFactor loading of > 0.20 represents positive associations, and <-0.20 represents negative associations
See this image and copyright information in PMC

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