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. 2024 Nov 27;14(11):e087006.
doi: 10.1136/bmjopen-2024-087006.

Prevalence of treatment-resistant depression and associated factors among major depressive disorder follow-up patients at Saint Amanuel Mental Specialised Hospital in Ethiopia: a cross-sectional study

Merga Siyoum  1 , Esayas Kibrom  2 , Tolesa Fanta  2 , Eyerusalem Matheyose  1 , Kemeriya Adem  1 , Deribe Bekele  3 , Henock Asfaw  4 , Samuel Demissie Darcho  5 , Jerman Dereje  6
Affiliations

Prevalence of treatment-resistant depression and associated factors among major depressive disorder follow-up patients at Saint Amanuel Mental Specialised Hospital in Ethiopia: a cross-sectional study

Merga Siyoum et al. BMJ Open. .

Abstract

Objectives: This study aimed to assess the prevalence of treatment-resistant depression (TRD) and associated factors among patients with major depressive disorder (MDD) on follow-up at Amanuel Mental Specialised Hospital, Addis Ababa, Ethiopia, 2021.

Design and setting: An institution-based cross-sectional study design was employed using systematic random sampling techniques from 17 February to 26 March 2021.

Participants: The study enrolled 412 participants with a response rate of 97.6%. The study population consisted of Saint Amanuel Mental Specialised Hospital follow-up patients with MDDs and all adult patients aged above 18.

Main outcome measures: The main outcome of this study was TRD, which was measured using the Hospital Anxiety and Depression Scale-Depression (HADS-D). The collected data were entered into Epi-data software version 3.1 and exported to the statistical package for social science version 20 for analysis. Bivariate and multivariate logistic regression analyses were used to identify associated factors with TRD. The OR with a 95% CI was used to assess the strength of the association.

Results: The prevalence of TRD was 41.5% (95% CI: 37.2 to 46.1). Female sex [AOR=2.43, 95% CI: 1.57 to 3.75], comorbid psychosis [AOR=1.89, 95% CI: 1.19 to 2.99], comorbid medical illness [AOR=1.67, 95% CI: 1.09 to 2.55] and family history of mental illness [AOR=2.27, 95% CI: 1.38 to 3.74] were factors significantly associated with TRD.

Conclusion and recommendation: In this study, the prevalence of TRD among patients with MDDs on follow-up was high. Therefore, to improve outcomes, screening for TRD and creating specific diagnostic techniques are necessary. Additionally, preventive interventions against TRD must be established.

Keywords: Burnout, Professional; CLINICAL PHARMACOLOGY; Caregiver Burden; Depression & mood disorders; Lipid disorders; PSYCHIATRY.

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Conflict of interest statement

Competing interests: None declared.

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