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. 2024 Nov 28;15(1):720.
doi: 10.1007/s12672-024-01582-0.

Improved lymph node detection in minimally invasive radical surgery for colorectal cancer using nanocarbon tracer

Bingkai Xie  1 , Guihe Lin  1 , Zhijian Wang  2 , Dongbo Xu  1 , Jianxun Chen  1 , Shuangming Lin  3
Affiliations

Improved lymph node detection in minimally invasive radical surgery for colorectal cancer using nanocarbon tracer

Bingkai Xie et al. Discov Oncol. .

Abstract

To investigate the influencing factors of lymph node detection after minimally invasive radical surgery in patients with colorectal cancer (CRC) and the application value of carbon nanoparticle tracing. A total of 120 patients with CRC who underwent minimally invasive radical surgery were included. They were divided into groups according to whether they were grouped by carbon nano-tracers, and the baseline data were matched by propensity score method. Univariate and multivariate methods were used to evaluate lymph nodes and positive lymph nodes after minimally invasive radical surgery. The number of detected independent factors. After propensity score matching, there were 37 patients in the tracer group and the non-tracer group; there was no significant difference in baseline data between the two groups; the number of positive lymph nodes detected in the tracer group was significantly higher than that in the non-tracer group. The results of univariate analysis showed that gender, lesion location, maximum tumor diameter, and whether to perform nanocarbon tracing were all related to the number of lymph nodes detected after minimally invasive radical surgery. Nanocarbon tracing was an independent influencing factor for the number of lymph nodes detected after minimally invasive radical surgery. Pathological type, T stage, histopathological grade, nerve invasion, and whether or not with cancer nodules were all related to the number of positive lymph nodes detected after minimally invasive radical surgery; multivariate analysis showed that T stage, pathological Histological grade, vascular invasion, and cancer nodules were all independent influencing factors for the number of positive lymph nodes detected after minimally invasive radical surgery. The number of lymph nodes detected in patients with CRC after minimally invasive radical surgery is closely related to the location of the lesion and whether carbon nanoparticle tracing is performed; those with T2-4 stage, histological grade 3-4, combined with vascular invasion and cancer nodules are more likely to Positive lymph nodes were detected.

Keywords: Colorectal cancer; Detection; Lymph node; Metastasis; Nano-carbon tracer.

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: This study was performed in compliance with all relevant ethical regulations, and all participants provided informed consent. The protocols for the collection of human samples in the study were approved by the Ethical Committee of Longyan First Affiliated Hospital of Fujian Medical University. All participants provided written informed consent to participate in this study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
The lymph nodes of the observation group were stained with nano-carbon
Fig. 2
Fig. 2
A schematic of results observed. B chi-square analysis of lymph node visualization based on diameter of 3 mm. C Comparison of number of lymph nodes less than 5 mm in both groups. D Comparison of number of metastasis-positive lymph nodes less than 5 mm in both groups
See this image and copyright information in PMC

References

    1. Ge W, Li Q, Liu WJ, et al. Carbon nanoparticle suspension could help get a more accurate nodal staging for patient with rectal cancer. Sci Rep. 2021;11(1):9933–40. - PMC - PubMed
    1. Li K, Chen D, Chen W, et al. A case-control study of using carbon nanoparticles to trace decision-making lymph nodes around inferior mesenteric artery in rectal cancer. Surg Endosc. 2019;33(3):904–10. - PubMed
    1. Wang D, Chen M, Lv L, et al. Injection of carbon nanoparticles for lymph node detection after laparoscopic colorectal cancer surgery. J Nanosci Nanotechnol. 2021;21(2):886–94. - PubMed
    1. Martín MJ, Gentili C, Lassalle V. In vitro biological tests as the first tools to validate magnetic nanotheranostics for colorectal cancer models. Chem Med Chem. 2020;15(12):1003–17. - PubMed
    1. Yang Q, Fu Y, Wang J, Yang H, Zhang X. Advantages of contrast-enhanced ultrasound in the localization and diagnostics of sentinel lymph nodes in breast cancer. J Zhejiang Univ Sci B. 2023;24(11):985–97. - PMC - PubMed

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