Cerebral magnetic resonance spectroscopy - insights into preterm brain injury
- PMID: 39609610
- PMCID: PMC11825355
- DOI: 10.1038/s41372-024-02172-2
Cerebral magnetic resonance spectroscopy - insights into preterm brain injury
Abstract
Objective: Magnetic resonance spectroscopy (1H-MRS) may provide clinically relevant data regarding metabolic processes that govern the course of preterm brain injury.
Study design: 46 very preterm infants (VP) were evaluated by magnetic resonance imaging and 1H-MRS at term-equivalent age. Brain injury was assessed according to the Kidokoro scale. Moreover, 17 term-born infants with hypoxic-ischemic encephalopathy (HIE) were scanned. The metabolic profile of the central nervous system was obtained from the bilateral thalamus.
Result: The Lipids/Creatine, Choline/Creatine, N-acetyl aspartate/Choline, Lactate/N-acetyl aspartate, and Lactate/Creatine ratios differed between VP infants with moderate+severe brain damage and those without brain injury. Moreover, VP infants with moderate+severe brain damage had higher Lactate/ N-acetyl aspartate and Lactate/Creatine ratios than HIE group.
Conclusion: There were significant differences in the cerebral metabolite profile at TEA between VP infants with and without brain injury. The 1H-MRS profile of VP infants with moderate+severe brain damage may reflect profound chronic metabolic alterations.
© 2024. The Author(s).
Conflict of interest statement
Statement of ethics: This study protocol was reviewed and approved by the Jagiellonian University Bioethical Committee, Krakow, Poland (approval number 1072.6120.336.2020). Written informed consent was obtained from the participants’ parents for participation in the study. All methods were performed in accordance with the relevant guidelines and regulations. Competing interests: The authors declare no competing interests.
Figures
Similar articles
-
Urinary Lactate-To-Creatinine Ratio during the First Days of Life Correlates with the Degree of Brain Damage in Premature Infants.Neonatology. 2025;122(2):222-231. doi: 10.1159/000542793. Epub 2024 Dec 10. Neonatology. 2025. PMID: 39657616 Free PMC article.
-
Third Trimester Cerebellar Metabolite Concentrations are Decreased in Very Premature Infants with Structural Brain Injury.Sci Rep. 2019 Feb 4;9(1):1212. doi: 10.1038/s41598-018-37203-4. Sci Rep. 2019. PMID: 30718546 Free PMC article.
-
Magnetic resonance spectroscopy in preterm infants: association with neurodevelopmental outcomes.Arch Dis Child Fetal Neonatal Ed. 2018 May;103(3):F238-F244. doi: 10.1136/archdischild-2016-311403. Epub 2017 Jul 19. Arch Dis Child Fetal Neonatal Ed. 2018. PMID: 28724545
-
Magnetic resonance spectroscopy.J Neuroophthalmol. 2005 Sep;25(3):217-26. doi: 10.1097/01.wno.0000177307.21081.81. J Neuroophthalmol. 2005. PMID: 16148633 Review.
-
Brain proton magnetic resonance spectroscopy and neurodevelopment after preterm birth: a systematic review.Pediatr Res. 2022 May;91(6):1322-1333. doi: 10.1038/s41390-021-01539-x. Epub 2021 May 5. Pediatr Res. 2022. PMID: 33953356
Cited by
-
Early parenteral lipid intake supports cerebellar neurometabolism at term-age in preterm infants.J Perinatol. 2025 Jun 23. doi: 10.1038/s41372-025-02336-8. Online ahead of print. J Perinatol. 2025. PMID: 40550844
References
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources