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Review
. 2024 Nov 28;22(1):27.
doi: 10.1186/s44342-024-00030-3.

Common genetic etiologies of sensorineural hearing loss in Koreans

Seung Hyun Jang #  1   2 , Kuhn Yoon #  3 , Heon Yung Gee  4   5   6
Affiliations
Review

Common genetic etiologies of sensorineural hearing loss in Koreans

Seung Hyun Jang et al. Genomics Inform. .

Abstract

Hearing loss is the most common sensory disorder. Genetic factors contribute substantially to this condition, although allelic heterogeneity and variable expressivity make a definite molecular diagnosis challenging. To provide a brief overview of the genomic landscape of sensorineural hearing loss in Koreans, this article reviews the genetic etiologies of nonsyndromic hearing loss in Koreans as well as the clinical characteristics, genotype-phenotype correlations, and pathogenesis of hearing loss arising from common variants observed in this population. Furthermore, potential genetic factors associated with age-related hearing loss, identified through genome-wide association studies, are briefly discussed. Understanding these genetic etiologies is crucial for advancing precise molecular diagnoses and developing targeted therapeutic interventions for hearing loss.

Keywords: Age-related hearing loss; Genome-wide association study; Genomic landscape; Hearing loss.

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Conflict of interest statement

Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Schematic illustration of inner ear structure. Cell types expressing common deafness-causative genes found in Koreans are indicated
See this image and copyright information in PMC

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References

    1. Richardson GP, de Monvel JB, Petit C. How the genetics of deafness illuminates auditory physiology. Annu Rev Physiol. 2011;73:311–34. - PubMed
    1. Jung J, Lee JS, Cho KJ, Yu S, Yoon JH, Yung Gee H, et al. Genetic predisposition to sporadic congenital hearing loss in a pediatric population. Sci Rep. 2017;7:45973. - PMC - PubMed
    1. Hilgert N, Smith RJ, Van Camp G. Function and expression pattern of nonsyndromic deafness genes. Curr Mol Med. 2009;9:546–64. - PMC - PubMed
    1. Oh KS, Walls D, Joo SY, Kim JA, Yoo JE, Koh YI, et al. COCH-related autosomal dominant nonsyndromic hearing loss: a phenotype-genotype study. Hum Genet. 2022;141:889–901. - PMC - PubMed
    1. Yamasoba T, Lin FR, Someya S, Kashio A, Sakamoto T, Kondo K. Current concepts in age-related hearing loss: epidemiology and mechanistic pathways. Hear Res. 2013;303:30–8. - PMC - PubMed

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