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. 2025 Oct 1;20(10):2921-2922.
doi: 10.4103/NRR.NRR-D-24-00726. Epub 2024 Oct 22.

Navigating the pathways: TAR-DNA-binding-protein-43 aggregation, axonal transport, and local synthesis in amyotrophic lateral sclerosis pathology

Ori Bar Avi  1 , Eran Perlson  1   2
Affiliations

Navigating the pathways: TAR-DNA-binding-protein-43 aggregation, axonal transport, and local synthesis in amyotrophic lateral sclerosis pathology

Ori Bar Avi et al. Neural Regen Res. .
No abstract available

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Figures

Figure 1
Figure 1
Scheme presenting possible bidirectional cause-and-effect connections between axonal transport and axonal TDP-43 aggregation. TDP-43 axonal aggregation may impair axonal transport by binding to motor proteins, directly interfering with their physical movement or sequestering of the motor proteins’ mRNAs. Alternatively, TDP-43 axonal aggregation may be the result of poor retrograde clearance or induced anterograde transport. Created with Adobe Illustrator. TDP-43: TAR DNA binding protein 43.
See this image and copyright information in PMC

References

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