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. 2024 Aug 5;23(2):2131-2142.
doi: 10.1007/s40200-024-01478-4. eCollection 2024 Dec.

Circulating mannose-binding lectin in diabetic patients and risk of vascular complications: a systematic review and meta-analysis

Mohammad Sedghi  1 , Ali Ranjbaran  2 , Mahtab Forouhi  3 , Mahdi Nejatianfar  4 , Nazanin Azmi-Naei  5 , Parian Pourmoafi Esfahani  6 , Mahdi Tavakoli  7 , Fatemeh Sadat Hashemi Javaheri  8 , Nazanin Shakibi  9 , Elham Mirzaee  10 , Akram Mirzaee  10 , Hannaneh Nejati  4 , Mansoureh Makarem  11 , Tahereh Parishan Kordiani  12 , Gita Pourshahikhaneh  12 , Rasoul Shavaleh  13 , Kazem Rahmani  13 , Molood Foogerdi  14
Affiliations

Circulating mannose-binding lectin in diabetic patients and risk of vascular complications: a systematic review and meta-analysis

Mohammad Sedghi et al. J Diabetes Metab Disord. .

Abstract

Objectives: Recent studies have confirmed the involvement of mannose-binding lectin (MBL) in the pathogenesis of vascular complications in individuals with diabetes. Due to the discrepancy between the results of studies, a meta-analysis was conducted to evaluate MBL levels in patients with diabetes and its vascular complications.

Methods: We reviewed all observational studies published in PubMed/Medline, Scopus, EMBASE, and Web of Science Core Collection databases to identify relevant studies up to 1 April 2024. To account for describing heterogeneity among the studies, I2 and χ2 statistics were utilized. Also, a random-effects model was employed to combine the studies. The Newcastle Ottawa Scale (NOS) checklist was applied for quality assessment of each study.

Results: Twenty-eight papers were encompassed in this meta-analysis. The mean difference in MBL levels between patients with diabetic nephropathy and diabetic retinopathy differed significantly compared with the healthy control group and the diabetic group without vascular complications (P-value < 0.05). Moreover, the pooled results revealed a significant relationship between MBL levels and the incidence of vascular complications (pooled HR = 1.44, 95% CI: 1.07-1.95, P-value < 0.05) and disease-related mortality (pooled HR = 1.52, 95% CI: 1.07-2.16, P-value < 0.05) among diabetic patients. Also, there was a direct association between incidence of nephropathy in diabetics and higher levels of MBL (pooled HR = 2.16, 95% CI: 1.52-3.08, P-value < 0.05).

Conclusion: Diabetic patients with elevated MBL levels are potentially at increased risk of vascular complications such as nephropathy and retinopathy. Therefore, by determining MBL status in diabetic patients, it is possible to predict the progress and possible consequences of the disease.

Keywords: Complement system; Diabetes; Inflammation; MBL; Vascular complications.

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Conflict of interest statement

Conflict of interestThe all authors declared that they have no conflict of interest in this study.

Figures

Fig. 1
Fig. 1
PRISMA flow diagram illustrating the process of study selection
Fig. 2
Fig. 2
Mean MBL levels in diabetic patients with nephropathy, retinopathy, and cardiovascular complications compared to the healthy control group
Fig. 3
Fig. 3
Mean MBL levels in diabetic patients with and without nephropathy, retinopathy and cardiovascular complications
Fig. 4
Fig. 4
Mean MBL levels in T1D and T2D patients with and without vascular complications
Fig. 5
Fig. 5
Mean MBL levels in T1D and T2D patients compared to the healthy control group
Fig. 6
Fig. 6
Incidence HR for diabetes-related vascular complications
Fig. 7
Fig. 7
Mortality HR for diabetes-related vascular complications
Fig. 8
Fig. 8
Funnel plot with pseudo 95% confidence limits for standardized mean MBL differences in diabetics with vascular complications
See this image and copyright information in PMC

References

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