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. 2024 Aug 9;23(2):2143-2149.
doi: 10.1007/s40200-024-01481-9. eCollection 2024 Dec.

Assessment of the initial results of pituitary tumor registry at a tertiary hospital of Iran: 2009-2022

Shahrzad Mohseni #  1 , Niloofar Mirdamadi #  1 , Shervin Mossavarali  2 , Mohammad Reza Mohajeri-Tehrani  1 , Mahnaz Pejman Sani  1
Affiliations

Assessment of the initial results of pituitary tumor registry at a tertiary hospital of Iran: 2009-2022

Shahrzad Mohseni et al. J Diabetes Metab Disord. .

Abstract

Objectives: The Pituitary Tumor Registry intends to provide a platform for clinical research and basic sciences, with an emphasis on disease outcomes.

Methods: In this retrospective cohort study, all patient data, including demographics, vital signs, symptoms and signs, medical history, medications, past drug history, paraclinical data, treatment modalities, post-surgery follow-up, treatment responsiveness, and pathology reports, have been gathered from the electronic patient records of the Endocrinology and Metabolism Research Center affiliated with Tehran University of Medical Sciences.

Results: A total of 200 patients with pituitary adenoma were identified. Acromegaly was the most prevalent adenoma, accounting for 35% (n = 70) of cases, followed by clinically nonfunctional pituitary adenoma (CNFPA) at 28.5% (n = 57), prolactinoma at 23% (n = 46), and Cushing disease at 13.5% (n = 27). All of the patients with Cushing disease had surgery, with trans-sphenoidal surgery accounting for 92.59%. Prolactinoma was mostly treated with medication (82.60% of cases). Post-operative complications were reported, including cerebrospinal fluid (CSF) leakage in CNFPA cases (24.13%, n = 7) and diabetes insipidus (DI) in acromegaly (13.46%, n = 7). Unfortunately, 5 patients died: two with acromegaly, two with CNFPA and one with Cushing disease.

Conclusions: This registry permits a comprehensive management, long term follow up and treatment outcomes of patients with pituitary adenomas.

Keywords: Acromegaly; Cushing disease; Non-functional adenoma; Pituitary adenoma; Pituitary tumors; Prolactinoma; Registry.

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Conflict of interest statement

Conflict of interestOn behalf of all authors, the corresponding author states that there is no conflict of interest.

Figures

Fig. 1
Fig. 1
Age of the participant based on their tumor type
Fig. 2
Fig. 2
Tumors based on their size
See this image and copyright information in PMC

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