Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Aug 29;23(2):2191-2199.
doi: 10.1007/s40200-024-01487-3. eCollection 2024 Dec.

Advanced 3D-DXA insights into bone density changes in hyperparathyroidism

Francesco Saverio Guerra  1 , Nicola Palladino  1 , Renaud Winzenrieth  2 , Giuseppe Guglielmi  1   3   4
Affiliations

Advanced 3D-DXA insights into bone density changes in hyperparathyroidism

Francesco Saverio Guerra et al. J Diabetes Metab Disord. .

Abstract

Objectives: Primary hyperparathyroidism (PHPT) is a disorder marked by chronic parathyroid hormone hypersecretion, which affects bone turnover and remodelling processes. With a loss of bone density and an increase in bone porosity, the cortical compartment is most severely impacted. The study's goal is to assess PHPT's effects on the volumetric bone mineral density (vBMD) of the femur's trabecular compartment as well as the vBMD and thickness of the cortical bone.

Methods: This is a retrospective case-control study, valuating age, biochemical doses, anthropometric measurements, and bone measurements. Between 2011 and 2016, 74 Caucasian Italian women and men with PHPT were sought out. Biochemical analyses were added to bone mineral density (BMD) values found in the lumbar spine and femoral neck. Proximal femur parameters such as cortical and trabecular volumetric (v) BMD, cortical thickness (CTh) and surface (s) BMD were analyzed by 3D-DXA software (3D-SHAPER Medical, Spain).

Results: The findings showed a negative correlation between PHPT patients and controls, which was equally affecting the cortical and trabecular compartments. This correlation was especially evident in the areal BMD (aBMD) and vBMD measurements. Nonetheless, no appreciable correlation was found between the cortical level and the thickness of the cortical bone.

Conclusions: Parathormone (PHT) levels had an adverse effect on the cortical, trabecular volumetric density in this investigation, as was expected. Cortical thickness, however, is unaffected significantly. The literature and these findings are consistent.

Keywords: 3D-DXA; Cortical bone; Hyperparathyroidism; Mineral density; Trabecular bone.

PubMed Disclaimer

Conflict of interest statement

Conflict of InterestEach author declares that he or she has no commercial associations (e.g. consultancies, stock ownership, equity interest, patent/licensing arrangement etc.) that might pose a conflict of interest in connection with the submitted article. The authors declared that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
3BMD* differences (∆) in % (nPHPT** subjects against controls) at the total femur, neck, trochanteric and shaft regions. *aBMD (areal bone mineral density); **PHPT (Primary hyperparathyroidism)
Fig. 2
Fig. 2
3D parameter differences (∆) in % (nPHPT* subjects against controls) at the total femur, neck, trochanteric and shaft regions. *PHPT (Primary hyperparathyroidism)
Fig. 3
Fig. 3
Anatomical distribution of percentage differences (nPHPT* subjects against controls) for the cortical parameters. Positive differences are in blue-green color while negative differences are in yellow–red color. Only significant differences are displayed. Grey color represents regions with no significant differences. *PHPT (Primary hyperparathyroidism)
Fig. 4
Fig. 4
Anatomical distribution of vBMD* differences (nPHPT** subjects against controls) in the mid-coronal and lower shaft cross sections. Positive differences are in blue-green color while negative differences are in yellow–red color. Only significant differences are displayed. Grey color represents regions with no significant differences. *vBMD (volumetric bone mineral density); **PHPT (Primary hyperparathyroidism)
See this image and copyright information in PMC

References

    1. Insogna KL. Primary Hyperparathyroidism. N Engl J Med. 2018;379(11):1050–9. 10.1056/NEJMcp1714213. - PubMed
    1. Lowe H, McMahon DJ, Rubin MR, Bilezikian JP, Silverberg SJ. Normocalcemic primary hyperparathyroidism: further characterization of a new clinical phenotype. J Clin Endocrinol Metab. 2007;92(8):3001–5. 10.1210/jc.2006-2802. - PubMed
    1. Bilezikian JP, Bandeira L, Khan A, Cusano NE. Hyperparathyroidism Lancet. 2018;391(10116):168–78. 10.1016/S0140-6736(17)31430-7. - PubMed
    1. Stein EM, Silva BC, Boutroy S, et al. Primary hyperparathyroidism is associated with abnormal cortical and trabecular microstructure and reduced bone stiffness in postmenopausal women. J Bone Miner Res. 2013;28(5):1029–40. 10.1002/jbmr.1841. - PMC - PubMed
    1. Khosla S, Melton LJ 3rd, Wermers RA, Crowson CS, O'Fallon Wm, Riggs Bl. Primary hyperparathyroidism and the risk of fracture: a population-based study. J Bone Miner Res. 1999;14(10):1700–7. 10.1359/jbmr.1999.14.10.1700. - PubMed

LinkOut - more resources