Assessing the efficacy of topical formulations in diabetic neuropathy: a narrative review
- PMID: 39610558
- PMCID: PMC11599498
- DOI: 10.1007/s40200-024-01459-7
Assessing the efficacy of topical formulations in diabetic neuropathy: a narrative review
Abstract
Background: We conducted a review of topical medications available for alleviation of diabetic neuropathic pain (DNP) and compared their efficacy with oral medications for pain relief. We also explored the feasibility of compounding topical medications.
Methods: Searches on PubMed, Medline Ovid, and Embase databases were conducted and findings were presented as a narrative review.
Results and discussion: 8% Capsaicin patches and 5% Lidocaine patches had the most evidence. The literature also showed evidence for topical clonidine, gabapentin, and amitriptyline.
Conclusion: Topical formulations are a potential substitute to oral medications in patients suffering from DNP. Potential options include 8% Capsaicin patch, 5% Lidocaine patch, Clonidine gel, Topical gabapentin, and an amitriptyline and ketamine combination. A promising area of research that requires further study is the effect of a combination of topicals in alleviated DNP.
Keywords: Compounding services; Localized neuropathic pain; Patient safety.
© The Author(s), under exclusive licence to Tehran University of Medical Sciences 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
Conflict of interest statement
Conflict of interestThe authors declared that they have no conflict of interest.
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